CD14
CD14 is a 55 kDa GPI-anchored glycoprotein expressed chiefly on monocytes, macrophages and neutrophils. It functions as a pattern-recognition co-receptor that binds lipopolysaccharide delivered by LPS-binding protein and presents endotoxin to MD-2 in the TLR4-MD-2 complex, thereby triggering NF-κB-driven innate immune responses. Soluble CD14 released from monocytes extends this activity to CD14-negative cells such as endothelium. The marker distinguishes classical CD14-positive monocytes from lymphocytes and is widely used to monitor monocyte reconstitution after transplantation. Dysregulated CD14 signaling underlies sepsis-associated cytokine storms, while CD14-positive macrophages in tumors correlate with immunosuppressive microenvironments.
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CD14 Protéines Recombinantes (8)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
