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United States

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Cat. No.: HY-136214

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R-BC154 acetate

R-BC154 acetate is a selective fluorescent α₉β₁ integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₅₇H₆₅N₉O₁₅S₃
Masse moléculaire:1212.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

R-BC154 acetate Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

α9β1

Voir tous les produits spécifiques à Isoform Integrin :

In Vitro

R-BC154 acetate has 3 times greater affinities for α₉β₁ (K_i=12.7 nM) relative to α₄β₁ (K_i=38.0 nM) under Ca²⁺/Mg²⁺ conditions in human glioblastoma LN18 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57Bl/6 mice (6-8 weeks old)^[1]
Dosage:

10 mg/kg
Administration:

Intravenous injection
Result:

Was capable of binding haemopoietic progenitor cells and HSC within mice bone marrow in vivo.

Chemical Information

Masse moléculaire 1212.37
Formule C₅₇H₆₅N₉O₁₅S₃
SMILES

CC(O)=O.CC/[N+](CC)=C1C=C2OC3=C(C=CC(N(CC)CC)=C3)C(C4=CC=C(S(NCC5=CN([C@H]6CN(S(=O)(C7=CC=CC=C7)=O)[C@H](C(N[C@H](C(O)=O)CC8=CC=C(OC(N9CCCC9)=O)C=C8)=O)C6)N=N5)(=O)=O)C=C4S(=O)([O-])=O)=C2C=C\1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org Biomol Chem. 2014 Feb 14;12(6):965-78. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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