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Cat. No.: HY-147235

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PROTAC RIPK2 Degrader-1

PROTAC RIPK2 Degrader-1 is a RIP2 kinase PROTAC degrader. PROTAC RIPK2 Degrader-1 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2143956-20-9
Formule: C₅₃H₆₅FN₁₄O₇S₂
Masse moléculaire:1093.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

PROTAC RIPK2 Degrader-1 Chemical Structure

CAS No.: 2143956-20-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

RIPK2

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform RIP kinase :

In Vitro

PROTAC RIPK2 Degrader-1 (example 25) can simultaneously bind RIP2 kinase and an E3 ubiquitin ligase (VHL), which promotes ubiquitination of RIP2 Kinase and leads to RIP2 kinase degradation by the proteasome. through proteolysis targeting chimeric molecules PROTACs technology, PROTAC RIPK2 Degrader-1 can promotes ubiquitination of RIP2 Kinaseand degrade RIP2 kinase with the concentrations of <1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

THP1 cells
Concentration:

﹤1 μM
Incubation Time:

12 h
Result:

Displayed > 80% degradation of RIP2 at concentrations ﹤1 μM.

Related Protocols :

Chemical Information

CAS No. 2143956-20-9
Masse moléculaire 1093.30
Formule C₅₃H₆₅FN₁₄O₇S₂
SMILES

O=C(N1CCC(CC1)[C@H](NC([C@H](C)NC)=O)C(N2[C@@](C3=NC(C(C4=CC=C(C=C4)F)=O)=CS3)([H])CCC2)=O)C5=CN=C(N=C5)N(CC6)CCN6CCOC(C(S(C(C)(C)C)(=O)=O)=C7)=CC8=C7C(NC9=NNC(C)=C9C)=NC=N8
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Conjugates comprising ripk2 inhibitors, WO2017182418 (example 25)

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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