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SKF 38393

24 Cited Publications
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Based on 24 publication(s) in Google Scholar

SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM). SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers.

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  • CAS No.: 67287-49-4
  • Formule: C16H17NO2
  • Masse moléculaire:255.31
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • SKF 38393 Chemical Structure
    SKF 38393 Chemical Structure
  • Experimental Validation Results for SKF 38393
  • Experimental Validation Results for SKF 38393
  • Experimental Validation Results for SKF 38393
  • Experimental Validation Results for SKF 38393
  • Experimental Validation Results for SKF 38393
CAS No.: 67287-49-4
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  • SKF 38393 Chemical Structure
    SKF 38393 Chemical Structure
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    SKF 38393 purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]

    Customer Validation
     SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.

  • 1/16

    SKF 38393 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]

    Customer Validation
     SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.

  • 1/16

    SKF 38393 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6. [Abstract]

    Customer Validation
     SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.

  • 1/16

    SKF 38393 purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]

    Customer Validation
     SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.

  • 1/16

    SKF 38393 purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]

    Customer Validation
     After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.

  • SKF 38393