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Tilatamig

(Synonyms: AZD9592 Antibody)
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Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).

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  • Pureté: 99.99%
  • CAS No.: 2868265-50-1
  • Masse moléculaire:144.77 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tilatamig
  • Experimental Validation Results for Tilatamig
  • Experimental Validation Results for Tilatamig
  • Experimental Validation Results for Tilatamig
  • Experimental Validation Results for Tilatamig
  • Tilatamig Chemical Structure
    Tilatamig Chemical Structure
CAS No.: 2868265-50-1
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Tilatamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-kappa

  • 1/16

    Immobilized EGFR Protein, Human (sf9, His-GST, HY-P72987) can bind Tilatamig. The EC50 for this effect is 945.9 ng/mL.

  • 1/16

    Immobilized HGFR Protein, Human (HEK293, His, HY-P70714) can bind Tilatamig. The EC50 for this effect is 7.134 ng/mL.

  • 1/16

    Flow Cytometry analysis of Hela cells labelling EGFR (red) with Tilatamig (HY-P990947). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow cytometric analysis of 1X106 HT-29 cells labeling MET with Tilatamig (HY-P990947, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Tilatamig Chemical Structure
    1/16
  • Tilatamig
  • Immobilized EGFR Protein, Human (sf9, His-GST, HY-P72987) can bind Tilatamig. The EC50 for this effect is 945.9 ng/mL.
  • Immobilized HGFR Protein, Human (HEK293, His, HY-P70714) can bind Tilatamig. The EC50 for this effect is 7.134 ng/mL.
  • Flow Cytometry analysis of Hela cells labelling EGFR (red) with Tilatamig (HY-P990947). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow cytometric analysis of 1X106 HT-29 cells labeling MET with Tilatamig (HY-P990947, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-lambda-kappa