Tipepidine citrate
Based on 1 publication(s) in Google Scholar
Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice.
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- CAS No.: 14698-07-8
- Formule: C21H25NO7S2
- Masse moléculaire:467.56
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Tipepidine citrate
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Activité biologique
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D2 Receptor |
Chemical Information
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CAS No. 14698-07-8
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Masse moléculaire 467.56
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Formule C21H25NO7S2
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SMILES
CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.O=C(CC(C(O)=O)(O)CC(O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model. [Abstract]2025 May;46(5):1190-1204. PMID: 39870847
Pureté et documentation
Références
[1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [Content Brief]
[2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. [Content Brief]
[3]. Kawaura K, et al. Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test. Eur J Pharmacol. 2011 Jan 25;651(1-3):106-8. [Content Brief]
[4]. Sawamoto A, et al. Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice. FASEB J. 2024 Mar 15;38(5):e23542. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tipepidine citrate Related Classifications
HY-B2185 Related Classifications
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