Candesartan
Based on 8 publication(s) in Google Scholar
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.10%
- No. CAS: 139481-59-7
- Fòrmula: C24H20N6O3
- Peso molecular:440.45
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-13955
TelmisartanAngiotensin II Type 1 Receptor -
HY-17512
LosartanAngiotensin II Receptor Antagonist -
HY-18204
ValsartanAngiotensin II Receptor Antagonist -
HY-B0202
IrbesartanAT1 Receptor Blocker -
HY-14914
AzilsartanAT1 Antagonist -
HY-17004
OlmesartanAT1R Antagonist -
HY-17512A
Losartan potassiumAT1 Antagonist -
HY-17505
Candesartan CilexetilAngiotensin II receptor Inhibitor -
HY-117743
EprosartanAngiotensin II Receptor Antagonist -
HY-B0780
FimasartanAngiotensin Receptor Antagonist -
HY-18206
LisinoprilACE Inhibitor -
HY-12765
Losartan Carboxylic AcidAT1 Antagonist
Publications Citing Use of MedChemExpress (MCE) Candesartan
More- J Immunother Cancer. 2026 Mar 25;14(3):e012426. [Abstract]
- Acta Pharmacol Sin. 2023 May;44(5):984-998. [Abstract]
- Free Radic Biol Med. 2023 May 1:200:59-72. [Abstract]
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Mol Med Rep. 2026 Apr;33(4):116. [Abstract]
- Mol Med Rep. 2022 Oct;26(4):318. [Abstract]
- Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]
- Preprints. 2026 Jun 19.
Customer Validation & Images
-
In Vivo Efficacy Study
-
In Vivo Efficacy Study
-
RT-PCR
-
WB
-
ELISA
Ver todos los productos específicos de isoformas Angiotensin Receptor
More
Actividad biológica
Descripciòn
IC50 & Target
|
PPAR-γ |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
0.69 nM
Compound: Candesartan
|
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
|
[PMID: 26824643] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice (nine-week-old, male, 22-28 g)[3]
-
Dosage:1 mg/kg
-
Administration:i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi.
-
Result:Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGFß1 while increasing expression of TGFB3.
Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 139481-59-7
-
Appearance Solid
-
Peso molecular 440.45
-
Fòrmula C24H20N6O3
-
Color White to off-white
-
SMILES
O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)O
-
Synonyms
CV 11974
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
-
Journal Impact Factor
-
Most Recent
-
J Immunother Cancer
Telmisartan increases olaparib efficacy in homologous recombination proficient tumors by augmenting type I interferon production. [Abstract]2026 Mar 25;14(3):e012426. PMID: 41881499 -
Acta Pharmacol Sin
Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation. [Abstract]2023 May;44(5):984-998. PMID: 36450791 -
Free Radic Biol Med
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway. [Abstract]2023 May 1:200:59-72. PMID: 36868433
Candesartan purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 May 1:200:59-72. [Abstract]
Effect of candesartan (1, 5 or 10 μg/kg/min) on the urine flow in SD rats fed the selenium-deficient diet for 16 weeks.
Candesartan purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 May 1:200:59-72. [Abstract]
Effect of candesartan (1, 5 or 10 μg/kg/min) on the urinary sodium excretion in SD rats fed the selenium-deficient diet for 16 weeks.
-
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Mol Med Rep
ULK1 activates NCOA4‑mediated ferritinophagy via the Beclin1/VPS34 complex in cardiomyocyte hypertrophy. [Abstract]2026 Apr;33(4):116. PMID: 41685593 -
Mol Med Rep
Angiotensin II receptor type 1 blocker candesartan improves morphine tolerance by reducing morphine‑induced inflammatory response and cellular activation of BV2 cells via the PPARγ/AMPK signaling pathway. [Abstract]2022 Oct;26(4):318. PMID: 36004465
Candesartan purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2022 Oct;26(4):318. [Abstract]
The expression levels of AT1R were detected by RT-qPCR after treatment of morphine-induced BV2 cells with candesartan.
Candesartan purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2022 Oct;26(4):318. [Abstract]
The expression levels of AT1R were detected by western blot after treatment of morphine-induced BV2 cells with candesartan.
Candesartan purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2022 Oct;26(4):318. [Abstract]
Candesartan dose-dependently inhibits inflammation in morphine-induced BV2 cells. The levels of TNF-α, IL-1β and IL-6 were detected by ELISA.
-
Biomedicines
Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1. [Abstract]2022 Dec 4;10(12):3131. PMID: 36551887
Candesartan purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]
Candesartan (5 μM; pretreat for 6 h) inhibits Ang II-induced CtBP1 expression in 3T3-L1 cells.
Candesartan purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]
Candesartan (5 μM; pretreat for 6 h) inhibits Ang II-induced CtBP1 transcription in 3T3-L1 cells.
-
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (227.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocolo
-
Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureza y Documentación
-
Ficha de datos (281 KB)
-
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66. [Content Brief]
[2]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38. [Content Brief]
[3]. Sonia Villapol, et al. Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012 Dec;37(13):2817-29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2704 mL | 11.3520 mL | 22.7041 mL | 56.7601 mL |
| 5 mM | 0.4541 mL | 2.2704 mL | 4.5408 mL | 11.3520 mL | |
| 10 mM | 0.2270 mL | 1.1352 mL | 2.2704 mL | 5.6760 mL | |
| 15 mM | 0.1514 mL | 0.7568 mL | 1.5136 mL | 3.7840 mL | |
| 20 mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.8380 mL | |
| 25 mM | 0.0908 mL | 0.4541 mL | 0.9082 mL | 2.2704 mL | |
| 30 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8920 mL | |
| 40 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4190 mL | |
| 50 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| 60 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 80 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7095 mL | |
| 100 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5676 mL |
Candesartan Related Classifications
HY-B0205 Related Classifications
Powered by Bioz