437982-89-3
437982-89-3
Chemical Structure
(S)-PHA533533
- CAS. Nr.: 437982-89-3
- Formula:C19H22N4O2
- Molecular Weight:338.40
InChIKey: UAOIPNOTWOYAMU-LBPRGKRZSA-N
SMILES: C[C@H](C(NC1=NNC(C2CC2)=C1)=O)C3=CC=C(N4CCCC4=O)C=C3
Biological Activity: (S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome[1].
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(S)-PHA533533 | 98.27% | (S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-162683A(R)-PHA533533 -
Similarity Score 0.60
HY-150082CP681301 -
Similarity Score 0.60
HY-163357CDK2/MDM2-IN-1 -
Similarity Score 0.58
HY-150889CDK9 ligand 1 -
Similarity Score 0.56
HY-123045PNU-292137 -
Similarity Score 0.56
HY-123772CDK5 inhibitor 20-223 -
Similarity Score 0.49
HY-156643Tacaciclib -
Similarity Score 0.49
HY-108375CDK9 ligand-Linker Conjugate 1 -
Similarity Score 0.47
HY-106000GSK239512 -
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