437982-89-3
437982-89-3
Chemical Structure
(S)-PHA533533
- CAS No.: 437982-89-3
- Formula:C19H22N4O2
- Molecular Weight:338.40
InChIKey: UAOIPNOTWOYAMU-LBPRGKRZSA-N
SMILES: C[C@H](C(NC1=NNC(C2CC2)=C1)=O)C3=CC=C(N4CCCC4=O)C=C3
Biological Activity: (S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome[1].
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(S)-PHA533533 | 98.27% | (S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome. | ||||||||||||||||||||
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References
Keywords
