CDK2/MDM2-IN-1

Cat. No.: HY-163357: FAQs
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CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC₅₀ value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

CDK2/MDM2-IN-1 Chemical Structure

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Description

CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC₅₀ value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity^[1].

In Vitro

CDK2/ MDM2-IN-1 (100, 200 nM, 4 h) inhibits the proliferation of tumor cells through CDK2/p-Rb and MDM2/p53 pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HCT116, OVCAR3
Concentration:	100, 200 nM
Incubation Time:	4 h
Result:	Reduced the expression of p-Rb, downstream of CDK2. Inhibited MDM2 protein expression and elevated p53 expression.

In Vivo

CDK2/MDM2-IN-1 (25, 50 mg/kg, intraperitoneal injection for 14 days) can significantly inhibit the proliferation of colon tumor cells in mice and does not affect the body weight of mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A nude mouse model of HCT116 transplanted tumor^[1]
Dosage:	25, 50 mg/kg
Administration:	i.p. for 14 days
Result:	Reduced tumor volume and weight.

Molecular Weight

479.57

Formula

C₂₆H₃₃N₅O₄

SMILES

[H][C@]1(C2=CC(NC(CC3=CC=C(N4CCCC4=O)C=C3)=O)=NN2)CC[C@@H](OC(N5CCC5(C)C)=O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu Z, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53. Molecules. 2024 Feb 4;29(3):725. [Content Brief]

CDK2/MDM2-IN-1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2/MDM2-IN-1CDKMDM-2/p53Cyclin dependent kinaseCDK2MDM2InhibitorAntitumorHCT116OVCAR3inhibitorinhibit

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