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Cetaben 

Cat. No.: HY-119964
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Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides.

For research use only. We do not sell to patients.

Cetaben Chemical Structure

Cetaben Chemical Structure

CAS No. : 55986-43-1

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10 mM * 1 mL in DMSO USD 107 In-stock
Estimated Time of Arrival: December 31
5 mg USD 135 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides[1][2].

In Vitro

Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles[2].
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells[2].

In Vivo

Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg[1].

Animal Model: Male Wistar rats[1]
Dosage: 10,25,50,100,250 and 500 mg/kg
Administration: Gavage; 10 day
Result: Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg.
Molecular Weight

361.56

Formula

C₂₃H₃₉NO₂

CAS No.

55986-43-1

SMILES

O=C(C1=CC=C(C=C1)NCCCCCCCCCCCCCCCC)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CetabenOthersexceptionalperoxisomeproliferatorPPARαnon-fibratehypolipidemicdrugcholesteroltriglyceridesInhibitorinhibitorinhibit

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HY-119964
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