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Art. -Nr.: HY-146035

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AChE-IN-14

AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.

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CAS. Nr.: 2390042-05-2
Formel: C₂₈H₃₅NO₃
Molecular Weight:433.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

AChE-IN-14 Chemical Structure

CAS. Nr.: 2390042-05-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

AChE

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

AChE-IN-14 (compound 5) has a good affinity to human H₃ receptor with a K_i value of 159.8 nM in HEK293 cells^[1].
AChE-IN-14 has a high orally activity and cannot cross the blood-brain barrier^[1].
AChE-IN-14 (10 μM, 5 min) inhibits hAChE with an IC₅₀ value of 0.48 μM and represents the non-competitive type of eeAChE (K_i = 176 nM) and eqBuChE (K_i = 281 nM) inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2390042-05-2
Molecular Weight 433.58
Formel C₂₈H₃₅NO₃
SMILES

O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Marek Bajda, et al. Search for new multi-target compounds against Alzheimer's disease among histamine H₃ receptor ligands. Eur J Med Chem. 2020 Jan 1;185:111785. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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AChE-IN-14

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AChE-IN-14 Related Classifications

HY-146035 Related Classifications

Bioz

Keywords

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