AEOL-10150 pentachloride
Based on 1 publication(s) in Google Scholar
AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant and a superoxide dismutase mimetic. AEOL-10150 pentachloride scavenges ROS and RNS, and modulates the NF-κB signaling pathway. AEOL-10150 pentachloride has potent antioxidant and anti-inflammatory activities. AEOL-10150 pentachloride effectively mitigates tissue damage caused by radiation and chemical agents such as CEES (HY-W199190). AEOL-10150 pentachloride synergizes with radiotherapy to exert anticancer effects on prostate tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 286475-30-7
- Formel: C48H56Cl5MnN12
- Molecular Weight:1033.24
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Immunology/Inflammation Compound Library
HY-L007
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Publications Citing Use of MedChemExpress (MCE) AEOL-10150 pentachloride
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Biologische Aktivität
AEOL-10150 (50 μM; 1 h after CEES exposure) pentachloride significantly reverses CEES (HY-W199190)-induced cell viability decline and DNA damage, and reduces cytoplasmic and mitochondrial ROS generation in mouse epidermal JB6 cells, human epidermal HaCaT cells, and normal human epidermal keratinocytes (NHEKs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AEOL-10150 (10-30 mg/kg/day; continuous infusion via subcutaneously implanted osmotic pump; 1-10 weeks) pentachloride significantly reduces pulmonary fibrosis, collagen deposition, and inflammation, and decreases respiratory rate and oxidative stress markers in rats with radiation-induced lung injury[3].
AEOL-10150 (5 mg/kg; s.c.; administered at 1 and 9 h post-exposure) pentachloride reduces protein, red blood cells, neutrophils, and oxidative stress markers in bronchoalveolar lavage fluid (BALF), improving lung injury in rats with CEES inhalation injury[5].
AEOL-10150 (6 mg/kg; i.p.; 16 days) pentachloride combined with radiotherapy (10 Gy) inhibits tumor growth more significantly than radiotherapy alone in C57BL/6 mice with RM-9 prostate tumor model[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 286475-30-7
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Appearance Solid
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Molecular Weight 1033.24
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Formel C48H56Cl5MnN12
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Color Light brown to black
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SMILES
CC[N+](C=CN1CC)=C1C2=C(C=CC3=C(C(N4CC)=[N+](C=C4)CC)C5=[N]6C(C=C5)=C7C(N8CC)=[N+](C=C8)CC)[N-]3[Mn+3]96[N]%10=C2C=CC%10=C(C(N%11CC)=[N+](C=C%11)CC)C%12=CC=C7[N-]9%12.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (120.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4.17 mg/mL (4.04 mM); Clear solution
This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 4.17 mg/mL (4.04 mM); Clear solution
This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (288 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Tewari-Singh N, et al. Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free Radic Biol Med. 2014 Jul;72:285-95. [Content Brief]
[2]. Zhang XR, et al. Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant. Mil Med Res. 2018;5(1):30. [Content Brief]
[3]. Rabbani ZN, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):573-80. [Content Brief]
[4]. O'Neill HC, et al. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 2011 Aug;45(2):323-31. [Content Brief]
[5]. O'Neill HC, et al. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radic Biol Med. 2010 May 1;48(9):1188-96. [Content Brief]
[6]. Ganesh D, et al. Impact of Superoxide Dismutase Mimetic AEOL 10150 on the Endothelin System of Fischer 344 Rats. PLoS One. 2016 Mar 18;11(3):e0151810. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9678 mL | 4.8391 mL | 9.6783 mL | 24.1957 mL |
| 5 mM | 0.1936 mL | 0.9678 mL | 1.9357 mL | 4.8391 mL | |
| 10 mM | 0.0968 mL | 0.4839 mL | 0.9678 mL | 2.4196 mL | |
| 15 mM | 0.0645 mL | 0.3226 mL | 0.6452 mL | 1.6130 mL | |
| 20 mM | 0.0484 mL | 0.2420 mL | 0.4839 mL | 1.2098 mL | |
| 25 mM | 0.0387 mL | 0.1936 mL | 0.3871 mL | 0.9678 mL | |
| 30 mM | 0.0323 mL | 0.1613 mL | 0.3226 mL | 0.8065 mL | |
| 40 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6049 mL | |
| 50 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4839 mL | |
| 60 mM | 0.0161 mL | 0.0807 mL | 0.1613 mL | 0.4033 mL | |
| 80 mM | 0.0121 mL | 0.0605 mL | 0.1210 mL | 0.3024 mL | |
| 100 mM | 0.0097 mL | 0.0484 mL | 0.0968 mL | 0.2420 mL |
AEOL-10150 pentachloride Related Classifications
HY-19416 Related Classifications
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