AN11736
AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC50s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models.
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- CAS. Nr.: 2152662-85-4
- Formel: C21H23BFNO5
- Molecular Weight:399.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
AN11736 exhibits excellent metabolic stability in mouse and bovine liver S9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:T. congolense and T. vivax infection model established in NMRI female mice or cattle
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.) or intramuscular injection (i.m.), single dose
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Result:Achieved a 100% cure rate with a single administration.
Chemical Information
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CAS. Nr. 2152662-85-4
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Molecular Weight 399.22
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Formel C21H23BFNO5
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SMILES
OB1OCC2=CC=C(C(N[C@@H](C(C)C)C(OCC3=CC=C(F)C=C3)=O)=O)C(C)=C21
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Akama T, et al. Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10. [Content Brief]
[2]. Wall RJ, et al. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AN11736 Related Classifications
HY-112905 Related Classifications
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