BIEGi-1
BIEGi-1 is an EGFR inhibitor. BIEGi-1 effectively disrupts the EGFR-Rheb interaction in cells. BIEGi-1 robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) as well as mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant cells. BIEGi-1 shows strong antiproliferative effects on EGFR-mutant PC9 and HCC827 cells with IC50 values of 17 nM and 20 nM, respectively. BIEGi-1 can be used for the study of cancers harboring EGFR mutations, such as non-small cell lung cancer (NSCLC).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1429497-30-2
- Formel: C36H37N7O3
- Molecular Weight:615.72
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle EGFR Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
mTORC1 |
BIEGi-1 (25 nM, 12 h) effectively disrupts the interaction between EGFR and Rheb in PC9 cells (EGFR-mutant)[1].
BIEGi-1 (25 nM, 12 h) robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) and mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant PC9 and HCC827 cells[1].
BIEGi-1 (0.01-10000 nM, 72 h) exerts strong antiproliferative effects on PC9 and HCC827 cells, with IC50 values of 17 nM and 20 nM, respectively[1].
BIEGi-1 (200 nM, 24 h) inhibits mTORC1 activation induced by lysosome-localized LAMP2-V5-EGFR-TKD (WT and KD) in serum-starved HEK-293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:EGFR-mutant PC9 and HCC827 cells
-
Concentration:25 nM
-
Incubation Time:12 h
-
Result:Reduced p-Y1068-EGFR and p-T389-S6K1 in EGFR-mutant PC9 and HCC827 cells.
Chemical Information
-
CAS. Nr. 1429497-30-2
-
Molecular Weight 615.72
-
Formel C36H37N7O3
-
SMILES
O=C1N(C2=CC(NC(/C=C/C)=O)=CC=C2)C3=NC(NC4=C(C=C(N5CCN(CC5)C)C=C4)OC)=NC=C3C=C1CC6=CC=CC=C6
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz