Art. -Nr.: HY-169925

BM-962

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BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC₅₀ value of 4 nM (K_i=0.8 nM) and Bcl-xL with an IC₅₀ value of 3.9 nM (K_i <1 nM). BM-962 inhibits the cell growth in H1417 and H146 cell lines with IC₅₀ values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers.

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Reinheit: 99.10%
CAS. Nr.: 1391107-57-5
Formel: C₅₃H₅₈ClF₃N₆O₇S₃
Molecular Weight:1079.71

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BM-962 Chemical Structure

CAS. Nr.: 1391107-57-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1417	IC₅₀	9 nM Compound: 31	Cytotoxicity against human H1417 cells assessed as growth inhibition after 4 days by WST-8 assay Cytotoxicity against human H1417 cells assessed as growth inhibition after 4 days by WST-8 assay	[PMID: 23030453]
NCI-H146	IC₅₀	13 nM Compound: 31	Cytotoxicity against human NCI-H146 cells assessed as growth inhibition after 4 days by WST-8 assay Cytotoxicity against human NCI-H146 cells assessed as growth inhibition after 4 days by WST-8 assay	[PMID: 23030453]

Chemical Information

CAS. Nr. 1391107-57-5
Appearance Solid
Molecular Weight 1079.71
Formel C₅₃H₅₈ClF₃N₆O₇S₃
Color White to off-white
SMILES

OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (185.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9262 mL

4.6309 mL

9.2617 mL

5 mM

0.1852 mL

0.9262 mL

1.8523 mL

10 mM

0.0926 mL

0.4631 mL

0.9262 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (4.63 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55(19):8502-14. [Content Brief]

[2]. Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9262 mL	4.6309 mL	9.2617 mL	23.1544 mL
	5 mM	0.1852 mL	0.9262 mL	1.8523 mL	4.6309 mL
	10 mM	0.0926 mL	0.4631 mL	0.9262 mL	2.3154 mL
	15 mM	0.0617 mL	0.3087 mL	0.6174 mL	1.5436 mL
	20 mM	0.0463 mL	0.2315 mL	0.4631 mL	1.1577 mL
	25 mM	0.0370 mL	0.1852 mL	0.3705 mL	0.9262 mL
	30 mM	0.0309 mL	0.1544 mL	0.3087 mL	0.7718 mL
	40 mM	0.0232 mL	0.1158 mL	0.2315 mL	0.5789 mL
	50 mM	0.0185 mL	0.0926 mL	0.1852 mL	0.4631 mL
	60 mM	0.0154 mL	0.0772 mL	0.1544 mL	0.3859 mL
	80 mM	0.0116 mL	0.0579 mL	0.1158 mL	0.2894 mL
	100 mM	0.0093 mL	0.0463 mL	0.0926 mL	0.2315 mL

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BM-962

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BM-962

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BM-962 Related Classifications

HY-169925 Related Classifications