BPH-1218
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent.
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- CAS. Nr.: 1426824-36-3
- Formel: C15H30N2O6P2
- Molecular Weight:396.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
0.17±0.04 μM (TgFPPS), 0.04±0.01 μM (TgCoq1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
11 μM
Compound: 27
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Activation of human CD4+ Vgamma2/Vdelta2 T cell clone JN.23 assessed as TNF-alpha release after 16 hrs by sandwich ELISA in presence of antigen presenting cell line, CP.EBV
Activation of human CD4+ Vgamma2/Vdelta2 T cell clone JN.23 assessed as TNF-alpha release after 16 hrs by sandwich ELISA in presence of antigen presenting cell line, CP.EBV
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[PMID: 23610597] |
Chemical Information
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CAS. Nr. 1426824-36-3
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Molecular Weight 396.36
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Formel C15H30N2O6P2
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SMILES
O=P(O)(C(P(O)(O)=O)C[N+]1=CN(CCCCCCCCCC)C=C1)[O-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Melissa A Sleda, wt al. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection. mBio. 2022 Oct 26;13(5):e0196622. [Content Brief]
[2]. M J Barry, et al. Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients? J Urol. 1995 Nov;154(5):1770-4. [Content Brief]
[3]. Na Shang, et al. Squalene Synthase As a Target for Chagas Disease Therapeutics. PLoS Pathog. 2014 May 1;10(5):e1004114. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BPH-1218 Related Classifications
HY-135625 Related Classifications
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