CDL36
CDL36 is a BAX inhibitor with an EC50 of 23.6 µM. CDL36 inhibits pro-apoptotic peptide-induced mitochondrial outer membrane permeabilization (MOMP). CDL36 exerts cytoprotective effects against Doxorubicin (HY-15142A)-induced cell death.
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- CAS. Nr.: 951529-42-3
- Formel: C29H32N6O2
- Molecular Weight:496.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Bax 23.6 μM (EC50) |
In Vitro
CDL36 (12.5-25 µM; 72 h) specifically protects intact CRISPR control cells and BAX knockout (KO) A549 cells against 5 µM Doxorubicin (HY-15142A)-induced cell death over a 72-hour treatment period[1].
CDL36 binds to recombinant BAX protein as determined by microscale thermophoresis, with an EC50 of 23.6 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 951529-42-3
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Molecular Weight 496.60
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Formel C29H32N6O2
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SMILES
CN(C1=C2C=CC=C1)C=C2C3=NN(CCC4=O)C(N4CC(N(CC5)CCN5C6=CC=CC(C)=C6C)=O)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDL36 Related Classifications
HY-187706 Related Classifications
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