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Art. -Nr.: HY-P990980

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Biologically Validated

Cizutamig

(Synonyms: CND-106; EMB-06)

Kundenbewertung

Based on 1 Customer Validation

Cizutamig (CND-106) is a bispecific T-cell engager targeting BCMA and CD3. Cizutamig exhibits immunostimulatory and anti-tumor activities. Cizutamig can be used in research related to relapsed or refractory multiple myeloma and systemic lupus erythematosus.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 95%
CAS. Nr.: 2919209-65-5
Molecular Weight:241.429 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cizutamig Chemical Structure

CAS. Nr.: 2919209-65-5

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Preis

Verfügbarkeit

Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

[L-kappa-H-gamma1_[VH-G1(CH1-h)]_Lkappa] dimer

Species Reactivity

Human

IC₅₀ & Target

TNFRSF17 & CD3E

In Vitro

Cizutamig exhibits binding affinity to BCMA-expressing myeloma cell lines comparable to that of T cell engagers (TCEs), while its binding affinity to CD3-positive Jurkat T cells is lower than that of the benchmark BCMA×CD3 TCE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cizutamig (0.5 mg/kg; intravenous administration; single dose) induces transient T cell margination, persistent B cell depletion, and mild transient cytokine induction in healthy cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys^[1]
Dosage:

0.5 mg/kg
Administration:

i.v.; single dose
Result:

Caused transient decrease in peripheral blood T cells indicative of margination.
Sustained reductions in circulating B cells.
Induced limited, transient cytokines.

Gene ID

608 [NCBI] & 916 [NCBI]

Accession

Q02223 & P07766

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Cizutamig on ProA biosensor, can bind BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78070) with an affinity constant of 8.191E-11 M as determined in BLI assay.

Chemical Information

CAS. Nr. 2919209-65-5
Appearance Liquid
Molecular Weight 241.429 kDa
Color Colorless to light yellow
SMILES

[Cizutamig]
Synonyms

CND-106; EMB-06
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Tan P, et al. POS1141 CND106, a novel BCMA-directed T-cell engager (TCE), has a differentiated safety profile and potential for development in autoantibody-driven autoimmune diseases. Annals of the Rheumatic Diseases, 2025, 84: 1217.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Cizutamig

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Antibody Inhibitor Library

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cizutamig Related Classifications

HY-P990980 Related Classifications