dGTP
Based on 1 publication(s) in Google Scholar
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP.
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- CAS. Nr.: 2564-35-4
- Formel: C10H16N5O13P3
- Molecular Weight:507.18
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
dGTP can be hydrolyzed to deoxyguanosine and triphosphate by dGTP triphosphohydrolase in E. coli, which acts as a key factor in regulating the size of the dGTP pool[1].
dGTP is oxidized to form 8-oxo-dGTP under the action of reactive oxygen species and other factors. During DNA replication, 8-oxo-dGTP can pair with C on the template strand, and also mispair with A. If it is incorporated into DNA without timely clearance, it will cause transversion mutations from A to C (or T to G), which is one of the main pathways of mutations induced by oxidative stress[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2564-35-4
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Appearance Solid
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Molecular Weight 507.18
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Formel C10H16N5O13P3
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Synonyms
2'-Deoxyguanosine-5'-triphosphate
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Most Recent
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Data Sheet (270 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6. [Content Brief]
[2]. Itsko M, et al. dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon. PLoS Genet. 2014;10(5):e1004310. Published 2014 May 8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
dGTP Related Classifications
HY-138616 Related Classifications
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