Art. -Nr.: HY-145963

DRB18

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DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity.

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Reinheit: 99.58%
CAS. Nr.: 2863686-81-9
Formel: C₂₂H₂₃ClN₂O₂
Molecular Weight:382.88

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DRB18 Chemical Structure

CAS. Nr.: 2863686-81-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

GLUT^[1]

Alle GLUT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1299	IC₅₀	1.9 μM Compound: 4v	Inhibition of glucose uptake in human NCI-H1299 cells incubated for 10 mins followed by L-[3H]2-deoxyglucose and glucose addition and measured after 30 mins by scintillation counting method Inhibition of glucose uptake in human NCI-H1299 cells incubated for 10 mins followed by L-[3H]2-deoxyglucose and glucose addition and measured after 30 mins by scintillation counting method	[PMID: 32736210]
NCI-H1299	IC₅₀	7 μM Compound: 4v	Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32736210]

In Vitro

DRB18 (0-10 μM; 30 min) reduces glucose uptake in GLUT1-4-expressed HEK293 cell lines in a dose-dependent manner with IC₅₀s varying from ~ 900 nM to ~ 9 μM^[1].
? DRB18 (5 and 10 μM; 72 hours) causes cell cycle arrest in the G1/S phase transition^[1].
? DRB18 (5 and 10 μM; 72 hours) increases ROS levels in A549 cells^[1].
? DRB18 (5 and 10 μM; 72 hours) reduces expression of glycosylated GLUT1 and GLUT2-4 in A549 cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

GLUT1-4-expressed HEK293 cell lines^[1]
Concentration:

0-10 μM
Incubation Time:

30 min
Result:

Reduced glucose uptake in these cell lines in a dose-dependent manner with IC₅₀s varying from ~ 900 nM to ~ 9 μM.

Cell Cycle Analysis

Cell Line:

A549^[1]
Concentration:

5 and 10 μM
Incubation Time:

72 hours
Result:

Caused cell cycle arrest in the G1/S phase transition.

Western Blot Analysis

Cell Line:

A549^[1]
Concentration:

5 and 10 μM
Incubation Time:

72 hours
Result:

Reduced expression of glycosylated GLUT1 and GLUT2-4 in A549 cells in a dose-dependent manner.

Western Blot Analysis

Cell Line:

A549^[1]
Concentration:

5 and 10 μM
Incubation Time:

72 hours
Result:

Reduced expression of glycosylated GLUT1 and GLUT2-4 in A549 cells in a dose-dependent manner.

In Vivo

DRB18 (10 mg/kg; IP; thrice a week for 5 weeks) inhibits tumors volume by 44% and tumors weight by 43%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male NU/J nude mice (3-4 weeks; tumor cell-injected)^[1]
Dosage:

10 mg/kg
Administration:

IP; thrice a week for 5 weeks
Result:

The tumors were 44% smaller by volume and 43% smaller by weight, also showed DRB18 decreased expression of GLUT1-4 (Fig. 5f) and reduced proliferative capacity within the xenografted tumor.

Chemical Information

CAS. Nr. 2863686-81-9
Appearance Solid
Molecular Weight 382.88
Formel C₂₂H₂₃ClN₂O₂
Color White to yellow
SMILES

ClC1=CC(NCC2=CC(O)=C(C)C=C2)=C(NCC3=CC=C(C)C(O)=C3)C=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Biochem Biophys Rep

Dimethyl-2-oxoglutarate but not antioxidants prevents glucose hypometabolism induced neural cell death: implications in the pathogenesis and therapy of Alzheimer's disease. [Abstract]

2025 Jul 12:43:102150. PMID: 40688502

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (130.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6118 mL

13.0589 mL

26.1178 mL

5 mM

0.5224 mL

2.6118 mL

5.2236 mL

10 mM

0.2612 mL

1.3059 mL

2.6118 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shriwas P, Roberts D, Li Y, et al. A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism. Cancer Metab. 2021;9(1):14. Published 2021 Mar 26. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6118 mL	13.0589 mL	26.1178 mL	65.2946 mL
	5 mM	0.5224 mL	2.6118 mL	5.2236 mL	13.0589 mL
	10 mM	0.2612 mL	1.3059 mL	2.6118 mL	6.5295 mL
	15 mM	0.1741 mL	0.8706 mL	1.7412 mL	4.3530 mL
	20 mM	0.1306 mL	0.6529 mL	1.3059 mL	3.2647 mL
	25 mM	0.1045 mL	0.5224 mL	1.0447 mL	2.6118 mL
	30 mM	0.0871 mL	0.4353 mL	0.8706 mL	2.1765 mL
	40 mM	0.0653 mL	0.3265 mL	0.6529 mL	1.6324 mL
	50 mM	0.0522 mL	0.2612 mL	0.5224 mL	1.3059 mL
	60 mM	0.0435 mL	0.2176 mL	0.4353 mL	1.0882 mL
	80 mM	0.0326 mL	0.1632 mL	0.3265 mL	0.8162 mL
	100 mM	0.0261 mL	0.1306 mL	0.2612 mL	0.6529 mL

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DRB18

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Glucose Metabolism Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) DRB18

Alle GLUT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DRB18

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Glucose Metabolism Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) DRB18

Alle GLUT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DRB18 Related Classifications

HY-145963 Related Classifications