RCHY1 - ring finger and CHY zinc finger domain containing 1 Gene

Also Known as ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25898

About RCHY1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,479,033-75,514,715 (from NCBI)

This gene has 13 transcripts (splice variants) and 155 orthologues. Ubiquitous expression in thyroid (RPKM 7.9), bone marrow (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene has ubiquitin Ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

RCHY1 Products (8)

mRNA Protein Name
NM_001009922.3 NP_001009922.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 3
NM_001278536.2 NP_001265465.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 4
NM_001278537.2 NP_001265466.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 5
NM_001278538.2 NP_001265467.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 6
NM_001278539.2 NP_001265468.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387136.1 NP_001374065.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387137.1 NP_001374066.1 RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_015436.4 NP_056251.2 RING finger and CHY zinc finger domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables p53 binding IPI
IPI: Inferred from physical interaction
19043414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15781263 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19483087 GOA
NOT enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
20452352 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19483087 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
19043414 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19483087 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
19483087 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
19483087 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19043414 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
33909987 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19483087 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15781263 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19483087 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
19043414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCHY1 Protein Structure

zf-CHY

zf-CHY: CHY zinc finger (20 - 94)

zf-RING_2

zf-RING_2: Ring finger domain (144 - 186)

zinc_ribbon_6

zinc_ribbon_6: Zinc-ribbon (191 - 250)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

RING finger and CHY zinc finger domain-containing protein 1

  • CH-rich interacting match with PLAG1

RCHY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RCHY1 Q96PM5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
25416956
Intra
RCHY1 Q96PM5 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
RCHY1 Q96PM5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Intra
RCHY1 Q96PM5 LIMS2 Homo sapiens Q7Z4I7-5
Y2H Array
25416956
Intra
RCHY1 Q96PM5 SEMA4C Homo sapiens Q9C0C4
Y2H Prey Pooling
25416956
Intra
RCHY1 Q96PM5 SEMA4C Homo sapiens Q9C0C4
Y2H Array
25416956
Intra
RCHY1 Q96PM5 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra
RCHY1 Q96PM5 ARF4 Homo sapiens P18085
Pull Down
21988832
Intra
RCHY1 Q96PM5 ARF4 Homo sapiens P18085
Confocal
21988832
Intra
RCHY1 Q96PM5 ARF4 Homo sapiens P18085
Y2H
21988832
Intra
RCHY1 Q96PM5 UBASH3B Homo sapiens Q8TF42
Anti Tag CoIP
33961781
Intra
RCHY1 Q96PM5 UBASH3B Homo sapiens Q8TF42
Y2H Array
25416956
Intra
RCHY1 Q96PM5 NKD2 Homo sapiens Q969F2
Y2H
21988832
Intra
RCHY1 Q96PM5 NKD2 Homo sapiens Q969F2
Anti Tag CoIP
21988832
Cross
RCHY1 Q96PM5 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Anti Tag CoIP
27519799
Cross
RCHY1 Q96PM5 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
BiFC
27519799
Intra
RCHY1 Q96PM5 CAMK2D Homo sapiens Q13557
Anti Tag CoIP
27519799
Intra
RCHY1 Q96PM5 TP53 Homo sapiens P04637
Anti Tag CoIP
17568776
Intra
RCHY1 Q96PM5 TP53 Homo sapiens P04637
Anti Tag CoIP
20452352
Intra
RCHY1 Q96PM5 NLK Homo sapiens Q9UBE8
Anti Tag CoIP
21988832
Intra
RCHY1 Q96PM5 NLK Homo sapiens Q9UBE8
Y2H
21988832
Intra
RCHY1 Q96PM5 NLK Homo sapiens Q9UBE8
Pull Down
21988832
Intra
RCHY1 Q96PM5 HRG Homo sapiens P04196
Anti Tag CoIP
21988832
Intra
RCHY1 Q96PM5 AIG1 Homo sapiens Q9NVV5
Pull Down
21988832
Intra
RCHY1 Q96PM5 AIG1 Homo sapiens Q9NVV5
Y2H
21988832
Intra
RCHY1 Q96PM5 AIG1 Homo sapiens Q9NVV5
Anti Tag CoIP
21988832
Intra
RCHY1 Q96PM5 ANGPTL8 Homo sapiens Q6UXH0
Y2H
21988832
Intra
RCHY1 Q96PM5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RCHY1 Q96PM5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RCHY1 Q96PM5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RCHY1 Q96PM5 KLHL41 Homo sapiens O60662
Y2H Prey Pooling
25416956
Intra
RCHY1 Q96PM5 KLHL41 Homo sapiens O60662
Y2H Array
25416956
Intra
RCHY1 Q96PM5 WDR74 Homo sapiens Q6RFH5
Y2H Prey Pooling
25416956
Intra
RCHY1 Q96PM5 WDR74 Homo sapiens Q6RFH5
Y2H Array
25416956
Intra
RCHY1 Q96PM5 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
RCHY1 Q96PM5 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Cross
RCHY1 Q96PM5 K9N7C7-PRO_0000422441 Middle East respiratory syndrome-related coronavirus K9N7C7-PRO_0000422441
Anti Tag CoIP
27519799
Cross: Cross-species interaction Intra: Intraspecies interaction

RCHY1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81998 Pirh2 Antibody (YA1743) WB Human
HY-P84738 Pirh2 Antibody (YA4435) WB, IHC-P, ICC/IF, FC, ELISA Human, Rat
HY-P84738A Pirh2 Antibody (YA4435)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Rat
HY-P85328 Pirh2 Antibody (YA5020) WB; ICC/IF; IP Human, Mouse

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11786 RCHY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RCHY1 VGNC VGNC:64549
Bos taurus RCHY1 VGNC VGNC:33829
Rattus norvegicus RCHY1 RGD RGD:1359180
Canis familiaris RCHY1 VGNC VGNC:45443
Macaca mulatta RCHY1 VGNC VGNC:76753
Mus musculus RCHY1 MGD MGI:1915348
Others RCHY1 NCBI