Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312299

About Ezh2

Primary_assembly 4: 76,624,399-76,687,362 reverse strand.mRatBN7.2:CM026977.1

This gene has 6 transcripts (splice variants), 237 orthologues, 23 paralogues and is associated with 59 phenotypes. Biased expression in Thymus (RPKM 228.6), Spleen (RPKM 17.5) and 9 other tissues.

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic Cancer. Human ortholog(s) of this gene implicated in Weaver syndrome; bone Cancer (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung Cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ezh2 Products (1)

mRNA Protein Name
NM_001134979.1 NP_001128451.1 histone-lysine N-methyltransferase EZH2

Ezh2 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (38 - 67)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (157 - 248)

preSET_CXC

preSET_CXC: pfam18264 (563 - 594)

SET_EZH2

SET_EZH2: cd19218 (613 - 732)

  • 0
  • 200
  • 400
  • 600
  • 751 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH2

  • enhancer of zeste homolog 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-13803 Tazemetostat Inhibitor 99.93% Yes

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-145602 Tulmimetostat Inhibitor 99.79% Phase 2
HY-13470 GSK126 Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (78)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-13500 GSK343 Inhibitor 99.85% Unkown
HY-10442 3-Deazaneplanocin A Inhibitor 99.97% Unkown
HY-12186 3-Deazaneplanocin A hydrochloride Inhibitor 99.98% Unkown
HY-15646 UNC1999 Inhibitor 99.87% Unkown
HY-133129 MS1943 Inhibitor 98.92% Unkown
HY-148333 MS177 Inhibitor 99.55% Unkown
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-147525 PROTAC EZH2 Degrader-1 Inhibitor 99.44% Unkown
HY-162250 MS8847 Inhibitor 99.78% Unkown
HY-103682 PF-06726304 Inhibitor 99.71% Unkown
HY-16986 EPZ011989 Inhibitor 98.75% Unkown
HY-N5024 Gambogenic acid Inhibitor 99.91% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-15555 EPZ005687 Inhibitor 99.46% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-157844 NUCC-0226272 Degrader 99.68% Unkown
HY-78694 5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide Ligand 98.22% Unkown
HY-100846 JQEZ5 Inhibitor 98.14% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-157164 PROTAC EZH2 Degrader-2 Degrader 98.77% Unkown
HY-15573 EI1 Inhibitor 98.84% Unkown
HY-147090 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Degrader 99.06% Unkown
HY-162384 EPIC-0628 Inhibitor 98.66% Unkown
HY-144330 TDI-6118 Inhibitor 99.08% Unkown
HY-A0298 EZH2-IN-2 Inhibitor 98.51% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-101508 GNA002 Inhibitor 95.73% Unkown
HY-146999 YM458 Inhibitor 99.16% Unkown
HY-131246 DM-01 Inhibitor 98.05% Unkown
HY-176165 CDK9/EZH2-IN-1 Inhibitor 99.08% Unkown
HY-119198 NSC745885 Inhibitor 98.0% Unkown
HY-147230 EZH2-IN-13 Inhibitor 99.72% Unkown
HY-111418 EBI-2511 Inhibitor 98.67% Unkown
HY-136188 UNC2399 Inhibitor 99.16% Unkown
HY-122936 Tanshindiol C Inhibitor 98.47% Unkown
HY-16986A EPZ011989 trifluoroacetate Inhibitor 98.71% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-144882 (R)-HH2853 Inhibitor / Unkown
HY-134899 CPI-1328 Inhibitor / Unkown
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / Unkown
HY-103682A PF-06726304 acetate Inhibitor / Unkown
HY-168131 PROTAC EZH2 Degrader-3 Degrader / Unkown
HY-177497 SKLB-03220 Inhibitor / Unkown
HY-178694 DC-PRC2in-01 Inhibitor / Unkown
HY-156292 IHMT-EZH2-426 Inhibitor / Unkown
HY-179351 EZH2 ligand-1 Ligand / Unkown
HY-179500 EZH2 ligand-Linker Conjugate 1 / Unkown
HY-149463 EZH2-IN-16 Inhibitor / Unkown
HY-163741 EZH2-IN-19 Inhibitor / Unkown
HY-181157 T/E PPI-IN-1 Inhibitor / Unkown
HY-181413 PROTAC EZH2 Degrader-44 Degrader / Unkown
HY-163288 EZH2/HSP90-IN-29 Inhibitor / Unkown
HY-179386 PARP1/EZH2-IN-1 Inhibitor / Unkown
HY-143616 EZH2-IN-7 Inhibitor / Unkown
HY-181327 PROTAC EZH2 Degrader-26 Degrader / Unkown
HY-122640 NPD13668 Inhibitor / Unkown
HY-179499 PROTAC EZH2 Degrader-9 Degrader / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-162601 D-01 Inhibitor / Unkown
HY-181331 PROTAC EZH2 Degrader-27 Inhibitor / Unkown
HY-184270 YM1240 Inhibitor / Unkown
HY-181319 PROTAC EZH2 Degrader-21 Degrader / Unkown
HY-181333 PROTAC EZH2 Degrader-38 Degrader / Unkown
HY-161083 PARP/EZH2-IN-2 Inhibitor / Unkown
HY-W1063360 EZH2 ligand-5 Ligand / Unkown
HY-141566 EZH2-IN-5 Inhibitor / Unkown
HY-139150 EZH2-IN-4 Inhibitor / Unkown
HY-181393 EZH2 ligand-3 Ligand / Unkown
HY-154854 BBDDL2059 Inhibitor / Unkown
HY-160423 MS8815N Control / Unkown
HY-181410 PROTAC EZH2 Degrader-41 / Unkown
HY-169958 EZH2-IN-22 Inhibitor / Unkown
HY-185582 EZH2 ligand-4 / Unkown
HY-116605 GSK926 Inhibitor / Unkown
HY-122115 DCE_42 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh2 NCBI NCBI:2146