PSMD2 - proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Gene
Also Known as S2; P97; RPN1; TRAP2
Species: Homo sapiens
About PSMD2
This gene has 20 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 64.5), brain (RPKM 40.8) and 25 other tissues.
Summary
The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in Proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
PSMD2 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001278708.2 | NP_001265637.1 | 26S proteasome non-ATPase regulatory subunit 2 isoform 2 |
| NM_001278709.2 | NP_001265638.1 | 26S proteasome non-ATPase regulatory subunit 2 isoform 3 |
| NM_002808.5 | NP_002799.3 | 26S proteasome non-ATPase regulatory subunit 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11278995 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| part of proteasome complex |
IDA
IDA: Inferred from direct assay
|
17323924 | GOA |
PSMD2 Protein Structure
PC_rep: Proteasome/cyclosome repeat (443 - 478)
PC_rep: Proteasome/cyclosome repeat (480 - 512)
- 0
- 200
- 400
- 600
- 800
- 908 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
26S proteasome non-ATPase regulatory subunit 2 |
|
PSMD2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | Q53XL8 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | Q53XL8 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | BAG1 | Homo sapiens | Q99933 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | BAG1 | Homo sapiens | Q99933 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | BAG1 | Homo sapiens | Q99933 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | BAG1 | Homo sapiens | Q99933 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | UCHL5 | Homo sapiens | Q9Y5K5 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | NEK7 | Homo sapiens | Q8TDX7 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | TBC1D3G | Homo sapiens | Q6DHY5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | TBC1D3G | Homo sapiens | Q6DHY5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | TBC1D3G | Homo sapiens | Q6DHY5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | TGFBR2 | Homo sapiens | P37173 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | TGFBR2 | Homo sapiens | P37173 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | TGFBR2 | Homo sapiens | P37173 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | SERPINH1 | Homo sapiens | P50454 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | SERPINH1 | Homo sapiens | P50454 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | SERPINH1 | Homo sapiens | P50454 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 19060904 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 19490896 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 19060904 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | PSMC1 | Homo sapiens | P62191 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | PSMD3 | Homo sapiens | O43242 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | PSMD3 | Homo sapiens | O43242 | 33961781 | |
|
Intra
|
PSMD2 | Q13200 | PSMD3 | Homo sapiens | O43242 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | PSMC5 | Homo sapiens | P62195 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | PSMD4 | Homo sapiens | P55036 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | PSMD4 | Homo sapiens | P55036 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | PSMC2 | Homo sapiens | P35998 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | PSMC2 | Homo sapiens | P35998 | 35271311 | |
|
Intra
|
PSMD2 | Q13200 | PSMC2 | Homo sapiens | P35998 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | MLF1 | Homo sapiens | P58340 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | RAD23A | Homo sapiens | P54725 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | RAD23A | Homo sapiens | P54725 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | RAD23A | Homo sapiens | P54725 | 32814053 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 25416956 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 16189514 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | UBLCP1 | Homo sapiens | Q8WVY7 | 33961781 | |
|
Cross
|
PSMD2 | Q13200 | Hacd3 | Mus musculus | Q8K2C9 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | VPS9D1 | Homo sapiens | Q9Y2B5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | VPS9D1 | Homo sapiens | Q9Y2B5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | VPS9D1 | Homo sapiens | Q9Y2B5 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | q53hb3_human | Homo sapiens | Q53HB3 | 25036637 | |
|
Intra
|
PSMD2 | Q13200 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | ADRM1 | Homo sapiens | Q16186 | 16990800 | |
|
Intra
|
PSMD2 | Q13200 | ZBTB39 | Homo sapiens | O15060 | 32296183 | |
|
Intra
|
PSMD2 | Q13200 | ZBTB39 | Homo sapiens | O15060 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Joubert Syndrome 7 |
|
|
| Cystic Fibrosis |
|
|
| Invasive Bladder Transitional Cell Carcinoma |
|
|
| Joubert Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | PSMD2 | VGNC | VGNC:69122 |
| Mus musculus | PSMD2 | MGD | MGI:1096584 |
| Macaca mulatta | PSMD2 | VGNC | VGNC:84144 |
| Bos taurus | PSMD2 | VGNC | VGNC:33466 |
| Rattus norvegicus | PSMD2 | RGD | RGD:1305752 |
| Canis familiaris | PSMD2 | VGNC | VGNC:45111 |
| Others | PSMD2 | NCBI |