Glycodeoxycholic acid-d5
Based on 1 Customer Validation
Glycodeoxycholic acid-d5 is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C26H38D5NO5
- Molecular Weight:454.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 360-65-6
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Molecular Weight 454.65
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Formel C26H38D5NO5
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SMILES
[H][C@@]12C([2H])([C@@]([2H])(C([2H])(C[C@@]1([C@H](C3CC2)C[C@H]([C@]4([C@]3(CC[C@@H]4[C@@H](CCC(NCC(O)=O)=O)C)[H])C)O)C)[2H])O)[2H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (274.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. [Content Brief]
[3]. Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65. [Content Brief]
[4]. Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1995 mL | 10.9975 mL | 21.9949 mL | 54.9874 mL |
| 5 mM | 0.4399 mL | 2.1995 mL | 4.3990 mL | 10.9975 mL | |
| 10 mM | 0.2199 mL | 1.0997 mL | 2.1995 mL | 5.4987 mL | |
| 15 mM | 0.1466 mL | 0.7332 mL | 1.4663 mL | 3.6658 mL | |
| 20 mM | 0.1100 mL | 0.5499 mL | 1.0997 mL | 2.7494 mL | |
| 25 mM | 0.0880 mL | 0.4399 mL | 0.8798 mL | 2.1995 mL | |
| 30 mM | 0.0733 mL | 0.3666 mL | 0.7332 mL | 1.8329 mL | |
| 40 mM | 0.0550 mL | 0.2749 mL | 0.5499 mL | 1.3747 mL | |
| 50 mM | 0.0440 mL | 0.2199 mL | 0.4399 mL | 1.0997 mL | |
| 60 mM | 0.0367 mL | 0.1833 mL | 0.3666 mL | 0.9165 mL | |
| 80 mM | 0.0275 mL | 0.1375 mL | 0.2749 mL | 0.6873 mL | |
| 100 mM | 0.0220 mL | 0.1100 mL | 0.2199 mL | 0.5499 mL |
Glycodeoxycholic acid-d5 Related Classifications
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