Guttiferone G
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla.
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- CAS. Nr.: 666174-75-0
- Formel: C43H58O6
- Molecular Weight:670.92
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 9 and 22 μM (SIRT1/2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.29 μM
Compound: 1; OC
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| AGS | IC50 |
4.58 μM
Compound: 1; OC
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Cytotoxicity against human AGS cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| HCC827 | IC50 |
9.2 μM
Compound: 1; OC
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Cytotoxicity against human HCC827 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCC827 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| HeLa | IC50 |
5.83 μM
Compound: 1; OC
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Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| HepG2 | IC50 |
12.96 μM
Compound: 1; OC
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Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| HT-29 | IC50 |
6.74 μM
Compound: 1; OC
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Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
| MIA PaCa-2 | IC50 |
4.46 μM
Compound: 1; OC
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Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 27396929] |
Chemical Information
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CAS. Nr. 666174-75-0
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Molecular Weight 670.92
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Formel C43H58O6
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SMILES
C/C(C)=C/C[C@](C([C@]12C/C=C(C)/C)=O)(C(C(C(C(C=C3)=CC(O)=C3O)=O)=C1O)=O)[C@](C)([C@@H](C2)C/C=C(C)/CC/C=C(C)/C)CC/C=C(C)/C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69(9):864-6. [Content Brief]
[2]. Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46(27):5219-22. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Guttiferone G Related Classifications
HY-N9892 Related Classifications
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