IST5-002
Based on 1 publication(s) in Google Scholar
IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.83%
- CAS. Nr.: 13484-66-7
- Formel: C17H20N5O7P
- Molecular Weight:437.34
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IST5-002
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Biologische Aktivität
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STAT5a 1.5 μM (IC50) |
STAT5b 3.5 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
7.7 μM
Compound: BAMP
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 25108359] |
| HCT-15 | IC50 |
0.8 μM
Compound: BAMP
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Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
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[PMID: 25108359] |
| HL-60 | IC50 |
5 μM
Compound: BAMP
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
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[PMID: 25108359] |
IST5-002 (1.5-25 μM, 2 h) inhibits transcriptional activity of Stat5a and Stat5b in a dose-dependent manner[1].
IST5-002 (0-40 μM, 3 h) inhibits Bcr-Abl-induced Stat5a/b phosphorylation in K562 cells[1].
IST5-002 (5-100 μM, 2 h) inhibits Stat5a/b phosphorylation in T47D cells, and inhibits dimerization in PC-3 cells[1].
IST5-002 (5-100 μM, 2 h) suppresses Stat5 nuclear translocation in PC-3 cells, and inhibits DNA binding of Stat5 target genes and COS-7 cells[1].
IST5-002 (2-50 μM, 48 h) reduces expression of Stat5a/b target genes (Bcl-xL and cyclin D1) in CWR22Rv1 and LNCaP cells[1].
IST5-002 (3.1-50 μM, 72 h) inhibits cell growth through induction of apoptosis in human prostate cancer cells[1].
IST5-002 (25-100 μM, 7 days) induces epithelial cell death in patient-derived prostate cancers ex vivo in organ explant cultures[1].
IST5-002 (5 μM, 24-72h) inhibits Stat5a/b phosphorylation and induces apoptosis of Imatinib (HY-15463)-sensitive and -resistant CML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CWR22Rv1, LNCaP, and DU145 cells
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Concentration:3.1, 6.3, 12.5, 25, 50 μM
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Incubation Time:72 h
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Result:Decreased viable cells by 50% to 80% at 12.5 μM.
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Cell Line:LNCaP and CWR22Rv1 cells
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Concentration:6, 12, 25 μM
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Incubation Time:72 h
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Result:Increased the fraction of dead cells (sub-G1) and decreased the fraction of living cells (G2–M).
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Cell Line:Bcr-Abl–positive K562 cells
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Concentration:0, 1, 5, 10, 20, 40 μM
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Incubation Time:3 h
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Result:Inhibited Bcr-Abl-induced Stat5a/b phosphorylation at 5 μM, without affecting Bcr-Abl tyrosine phosphorylation levels.
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Cell Line:PC-3 cells
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Concentration:5, 10, 15. 20, 40 μM
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Incubation Time:2 h
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Result:Inhibited Prl (Prolactin)-induced nuclear translocation of Stat5.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Prostate cancer (CWR22Rv1) xenograft model[1]
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Dosage:25, 50, and 100 mg/kg
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Administration:Intraperitoneal injection, daily for 10 days
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Result:Induced massive loss of viable tumor cells and dead rounded cells accumulation.
Induced cell death through apoptosis (shown by fragmented DNA in tumor sections).
Decreased nuclear Stat5a/b content by 60%, 78%, and 90% at 25, 50, and 100 mg/kg, respectively.
Chemical Information
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CAS. Nr. 13484-66-7
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Appearance Solid
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Molecular Weight 437.34
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Formel C17H20N5O7P
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Color White to off-white
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SMILES
O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)NCC4=CC=CC=C4)O1)O)O)O
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Synonyms
N6-Benzyladenosine-5'-phosphate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Exp Eye Res
Targeting STAT5 attenuates retinal neovascularization by promoting apoptosis and suppressing endothelial cell function. [Abstract]2026 Feb:263:110788. PMID: 41349784
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (285.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 125 mg/mL (285.82 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2866 mL | 11.4328 mL | 22.8655 mL | 57.1638 mL |
| 5 mM | 0.4573 mL | 2.2866 mL | 4.5731 mL | 11.4328 mL | |
| 10 mM | 0.2287 mL | 1.1433 mL | 2.2866 mL | 5.7164 mL | |
| 15 mM | 0.1524 mL | 0.7622 mL | 1.5244 mL | 3.8109 mL | |
| 20 mM | 0.1143 mL | 0.5716 mL | 1.1433 mL | 2.8582 mL | |
| 25 mM | 0.0915 mL | 0.4573 mL | 0.9146 mL | 2.2866 mL | |
| 30 mM | 0.0762 mL | 0.3811 mL | 0.7622 mL | 1.9055 mL | |
| 40 mM | 0.0572 mL | 0.2858 mL | 0.5716 mL | 1.4291 mL | |
| 50 mM | 0.0457 mL | 0.2287 mL | 0.4573 mL | 1.1433 mL | |
| 60 mM | 0.0381 mL | 0.1905 mL | 0.3811 mL | 0.9527 mL | |
| 80 mM | 0.0286 mL | 0.1429 mL | 0.2858 mL | 0.7145 mL | |
| 100 mM | 0.0229 mL | 0.1143 mL | 0.2287 mL | 0.5716 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
IST5-002 Related Classifications
HY-19527 Related Classifications
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