ITF5924
ITF5924 (compound 1) is a potent and highly selective HDAC6 inhibitor with an IC50 of 7.7 nM. ITF5924 shows greater than 104-fold selectivity for HDAC6 over all other HDAC subtypes. ITF5924 containing a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety is slow-binding substrate analog of HDAC6 that undergo an enzyme-catalyzed ring opening reaction, forming a tight and long-lived enzyme-inhibitor complex.
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- CAS. Nr.: 2760854-72-4
- Formel: C21H18F2N8O
- Molecular Weight:436.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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HDAC6 7.7 nM (IC50) |
Chemical Information
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CAS. Nr. 2760854-72-4
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Molecular Weight 436.42
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Formel C21H18F2N8O
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SMILES
FC(F)C(O1)=NN=C1C(C=C2)=CC=C2CN3N=NC(C4=CC=C(NC5=NCCN5)C=C4)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ITF5924 Related Classifications
HY-161306 Related Classifications
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