MPI8
MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 856242-63-2
- Formel: C32H48N4O7
- Molecular Weight:600.75
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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SARS-CoV‑2 Main Protease |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
70 μM
Compound: MPI8
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38608245] |
| Vero C1008 | CC50 |
>200 μM
Compound: 105
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CCK8 assay
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[PMID: 34798775] |
Chemical Information
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CAS. Nr. 856242-63-2
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Molecular Weight 600.75
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Formel C32H48N4O7
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SMILES
O=C(N[C@H](C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC2CCCCC2)=O)[C@@H](C)OC(C)(C)C)OCC3=CC=CC=C3
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Synonyms
TG0205221
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Ma X R, et al. MPI8 is potent against SARS‐CoV‐2 by inhibiting dually and selectively the SARS‐CoV‐2 main protease and the host cathepsin L[J]. ChemMedChem, 2022, 17(1): e202100456. [Content Brief]
[2]. Yang S, et al. Synthesis, crystal structure, structure− activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor[J]. Journal of medicinal chemistry, 2006, 49(16): 4971-4980. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MPI8 Related Classifications
HY-158763 Related Classifications
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