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Art. -Nr.: HY-155785

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MTP

MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma.

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CAS. Nr.: 2377372-62-6
Formel: C₂₉H₂₃F₃N₄O₂
Molecular Weight:516.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MTP Chemical Structure

CAS. Nr.: 2377372-62-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

JAK2

Alle JAK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MCF7	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MDA-MB-231	IC₅₀	0.1 μM Compound: 1; Tr-87	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1650	IC₅₀	0.2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1975	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H460	IC₅₀	1.5 μM Compound: 1; Tr-87	Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-3	IC₅₀	0.6 μM Compound: 1; Tr-87	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-9	IC₅₀	0.5 μM Compound: 1; Tr-87	Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 2377372-62-6
Molecular Weight 516.51
Formel C₂₉H₂₃F₃N₄O₂
SMILES

C#CC(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)CCC(NC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Weng JR, et al. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chem Biol Interact. 2023 Aug 1;380:110538. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
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MTP

Alle JAK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MTP Related Classifications

HY-155785 Related Classifications