Patulin
Based on 4 publication(s) in Google Scholar
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
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- Reinheit: 99.94%
- CAS. Nr.: 149-29-1
- Formel: C7H6O4
- Molecular Weight:154.12
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) Patulin
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Biologische Aktivität
Patulin (2 μM, 6-24 h) induces LMP and reduces Cathepsin B release in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) increases cytochrome c protein level and leads apoptosis induction in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) impairs mitophagy in HepG2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:2 μM
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Incubation Time:6-24 h
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Result:Increased the levels of active cleaved caspase-3 at 12 or 24 h.
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Cell Line:HepG2 cells
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Concentration:2 μM
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Incubation Time:3-24 h
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Result:Increases the LC3-II levels.
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Cell Line:HepG2 cells
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Concentration:2 μM
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Incubation Time:6-24 h
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Result:Increased the numbers of swollen mitochondria with scarce or disordered cristae.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CF-1 mice[4]
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Dosage:1-3.75 mg/kg
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Administration:i.p., once time
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Result:Increased the damage index and TBARS production in the brain, liver and kidneys of mice in a dose-dependently manner (2.5-3.75 mg/kg).
Reduced the concentration of the reduced form of intracellular glutathione in the brain, liver and kidneys of mice at a dose of 2.5-3.75 mg/kg.
Decreased the levels of GSH.
Increased lipid peroxidation.
Chemical Information
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CAS. Nr. 149-29-1
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Appearance Solid
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Molecular Weight 154.12
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Formel C7H6O4
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Color White to off-white
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SMILES
O=C1OC2=CCOC(C2=C1)O
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Synonyms
Terinin
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Structure Classification
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Initial Source
Penicillium and Aspergillus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration. [Abstract]2023 Sep 11;12(9):1750. PMID: 37760053 -
Anal Chem
Highly Sensitive Chemiluminescent Immunoassay of Mycotoxins Using ZIF-8-Derived Yolk-Shell Co Single-Atom Site Catalysts as Superior Fenton-like Probes. [Abstract]2022 Feb 22;94(7):3400-3407. PMID: 35138805 -
Anal Chim Acta
CoN4-supported Co2N metal clusters for developing sensitive chemiluminescent immunochromatographic assays. [Abstract]2022 Nov 1:1232:340478. PMID: 36257748 -
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (648.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (324.42 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (16.22 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (419 KB)
- English - EN (419 KB)
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- Norwegian - NO (419 KB)
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- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Puel O, et al. Biosynthesis and toxicological effects of patulin. Toxins (Basel). 2010 Apr;2(4):613-31. [Content Brief]
[2]. Glaser N, et al. Patulin: Mechanism of genotoxicity. Food Chem Toxicol. 2012 May;50(5):1796-801. [Content Brief]
[3]. Sun M, et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells. J Agric Food Chem. 2018 Nov 21;66(46):12376-12384. [Content Brief]
[4]. Glaser N, et al. Patulin: Mechanism of genotoxicity. Food Chem Toxicol. 2012 May;50(5):1796-801. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.4885 mL | 32.4423 mL | 64.8845 mL | 162.2113 mL |
| 5 mM | 1.2977 mL | 6.4885 mL | 12.9769 mL | 32.4423 mL | |
| 10 mM | 0.6488 mL | 3.2442 mL | 6.4885 mL | 16.2211 mL | |
| 15 mM | 0.4326 mL | 2.1628 mL | 4.3256 mL | 10.8141 mL | |
| 20 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1106 mL | |
| 25 mM | 0.2595 mL | 1.2977 mL | 2.5954 mL | 6.4885 mL | |
| 30 mM | 0.2163 mL | 1.0814 mL | 2.1628 mL | 5.4070 mL | |
| 40 mM | 0.1622 mL | 0.8111 mL | 1.6221 mL | 4.0553 mL | |
| 50 mM | 0.1298 mL | 0.6488 mL | 1.2977 mL | 3.2442 mL | |
| 60 mM | 0.1081 mL | 0.5407 mL | 1.0814 mL | 2.7035 mL | |
| 80 mM | 0.0811 mL | 0.4055 mL | 0.8111 mL | 2.0276 mL | |
| 100 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Patulin Related Classifications
HY-N6779 Related Classifications
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