Reticulol
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma.
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- CAS. Nr.: 26246-41-3
- Formel: C11H10O5
- Molecular Weight:222.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Reticulol (25-200 μM) shows a potent cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pathogen-free female C57BL/6J mice[1]
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Dosage:10 mg/kg, 50 mg/kg
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Administration:IV via the tail vein; day 3 and day 5 after tumor implanted
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Result:Inhibited tumor growth.
Chemical Information
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CAS. Nr. 26246-41-3
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Molecular Weight 222.19
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Formel C11H10O5
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SMILES
O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1
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Synonyms
K 251-1
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Structure Classification
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Initial Source
Streptoverticillium album
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60. [Content Brief]
[2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reticulol Related Classifications
HY-120241 Related Classifications
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