RO5234444
RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy.
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- CAS. Nr.: 1365266-79-0
- Formel: C24H31ClFN3O3
- Molecular Weight:463.97
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Human CCR2 22 nM (IC50) |
Mouse CCR2 161 nM (IC50) |
Chemical Information
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CAS. Nr. 1365266-79-0
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Molecular Weight 463.97
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Formel C24H31ClFN3O3
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SMILES
O=C1N(CCCN(CC2)C[C@@H](O)C32CC3)CCN(C(/C=C/C4=CC=C(F)C(Cl)=C4)=O)[C@H]1C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RO5234444 Related Classifications
HY-100819 Related Classifications
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