Scr-IN-2
Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer.
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- CAS. Nr.: 2787582-78-7
- Formel: C21H33N7
- Molecular Weight:383.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Scr-IN-2 (Compound 3g) inhibits MDAMB-231, T47D, and MCF-7 cell proliferation with IC50s of 0.812, 1.03 and 0.568 μM, and shows no significant toxicity to normal breast cells (MCF-10A)[1].
Scr-IN-20 (500 nM, 48 h) increases the ROS production, causes damage to mitochondria, induces apoptosis and halts the cell cycle at the G1 phase in the MCF-7 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:500 nM
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Incubation Time:48 h
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Result:Reached the proportion of apoptotic cells by 62.5%.
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Cell Line:MCF-7 cells
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Concentration:500 nM
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Incubation Time:48 h
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Result:Blocked MCF-7 cells in the G1 phase to inhibit DNA replication and cell proliferation.
Chemical Information
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CAS. Nr. 2787582-78-7
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Molecular Weight 383.53
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Formel C21H33N7
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SMILES
CCCCN1C(NC(C)(C)C)=NC2=CC=CC=C2C1C3=NN=NN3C(C)(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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