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Art. -Nr.: HY-122679

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UU-T03

UU-T03 is a β-catenin/Tcf protein-protein interaction inhibitor and an inhibitor of Wnt signaling activation. UU-T03 downregulates the expression of AXIN2, LGR5, cyclin D1, and c-myc. UU-T03 inhibits the growth of colorectal cancer cells. UU-T03 can be used for research on colorectal cancer.

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CAS. Nr.: 1586007-00-2
Formel: C₃₇H₄₁ClN₄O₉
Molecular Weight:721.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

UU-T03 Chemical Structure

CAS. Nr.: 1586007-00-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Wnt Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SW480	IC50	28.73 μM	Inhibition of Wnt-responsive luciferase activity in human SW480 colorectal cancer cells transfected with TOPFlash reporter. Inhibition of Wnt-responsive luciferase activity in human SW480 colorectal cancer cells transfected with TOPFlash reporter.	24191653
HEK293	IC50	37.57 μM	Inhibition of Wnt-responsive luciferase activity in Wnt-activated human HEK293 cells co-transfected with β-catenin and TOPFlash reporter. Inhibition of Wnt-responsive luciferase activity in Wnt-activated human HEK293 cells co-transfected with β-catenin and TOPFlash reporter.	24191653
SW480	IC50	10.77 μM	Antiproliferative activity against human SW480 colorectal cancer cells assessed as growth inhibition by MTs assay. Antiproliferative activity against human SW480 colorectal cancer cells assessed as growth inhibition by MTs assay.	24191653
HT-29	IC50	11.01 μM	Antiproliferative activity against human HT29 colorectal cancer cells assessed as growth inhibition by MTs assay. Antiproliferative activity against human HT29 colorectal cancer cells assessed as growth inhibition by MTs assay.	24191653
HCT-116	IC50	28.83 μM	Antiproliferative activity against human HCT116 colorectal cancer cells assessed as growth inhibition by MTs assay. Antiproliferative activity against human HCT116 colorectal cancer cells assessed as growth inhibition by MTs assay.	24191653
HEK293	IC50	84.02 μM	Cytotoxicity against normal human HEK293 cells assessed as cell viability reduction by MTs assay. Cytotoxicity against normal human HEK293 cells assessed as cell viability reduction by MTs assay.	24191653

In Vitro

UU-T03 (Compound 21) inhibits Wnt-responsive luciferase activity in SW480 and Wnt-activated HEK293 cells with IC₅₀ values of 28.73 µM and 37.57 µM, respectively, without affecting FOPFlash activity^[1].
UU-T03 downregulates AXIN2, LGR5, cyclin D1, and c-myc mRNA in SW480 cells in a dose-dependent manner^[1].
UU-T03 (7.5-60 µM) reduced cyclin D1 and c-myc protein levels in SW480 cells without affecting β-catenin protein^[1].
UU-T03 (0-60 µM) selectively disrupts β-catenin/Tcf interactions in HCT116 cells in a dose-dependent manner, without affecting β-catenin/cadherin and β-catenin/APC interactions^[1].
UU-T03 inhibited the growth of SW480, HT29, and HCT116 colorectal cancer cells with IC₅₀ values of 10.77, 11.01, and 28.83 µM, respectively, and exhibited an IC₅₀ of 84.02 µM in normal HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 1586007-00-2
Molecular Weight 721.20
Formel C₃₇H₄₁ClN₄O₉
SMILES

C(C(N[C@@H](CC1=CC2=C(C=C1)C=CC=C2)C(N[C@H](C(N[C@@H](CCC(OCC)=O)C(OC)=O)=O)CC(OCC)=O)=O)=O)C=3NC=4C(C3)=CC(Cl)=CC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS chemical biology. 2014 Jan 17;9(1):193-201. [Content Brief]

[2]. Pećina-Šlaus N, et al. Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International journal of molecular sciences. 2023 Apr 04;24(7):6733. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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