Z21115
Z21115 is an orally active inhibitor for phosphodiesterase 4 (PDE4), that inhibits PDE4D7 with IC50 of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg).
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- CAS. Nr.: 2958668-54-5
- Formel: C20H20F2N2O4
- Molecular Weight:390.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PDE4D7 10.5 nM (IC50) |
PDE4D 65.7 nM (IC50) |
PDE4B 64.4 nM (IC50) |
Chemical Information
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CAS. Nr. 2958668-54-5
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Molecular Weight 390.38
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Formel C20H20F2N2O4
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SMILES
COC1=C(OC)C=C(C2=CC=C(OC(F)F)C3=NN(C4CC4)C=C23)C=C1OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Z21115 Related Classifications
HY-161936 Related Classifications
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