Argipressin
Based on 10 publication(s) in Google Scholar
Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
For research use only. We do not sell to patients.
- Purity: 98.71%
- CAS No.: 113-79-1
- Formula: C46H65N15O12S2
- Molecular Weight:1084.23
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Argipressin
More- Nat Chem Biol. 2026 Jan 6. [Abstract]
- Chemosphere. 2021 Apr;269:128776. [Abstract]
- Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
- J Ethnopharmacol. 2025 Apr 9:119679. [Abstract]
- Front Pharmacol. 2019 Nov 15;10:1380. [Abstract]
- J Cell Mol Med. 2022 Nov;26(21):5493-5505. [Abstract]
- Front Neurosci. 2022 Mar 25;16:838942. [Abstract]
- BMC Pulm Med. 2021 Jun 5;21(1):189. [Abstract]
- Research Square Preprint. 2023 Sep 11.
- The Pharma Innovation. 2020; 9(7): 553-560.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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WB
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Cell Imaging/Staining
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IF
All Vasopressin Receptor Isoforms
More
Biological Activity
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V2 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A7R5 | IC50 |
10 nM
Compound: vasopressin, VS2
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Tested for the TYR(Me)2 arginine-vasopressin as radioligand at 0.3 nM in A7r5 cells
Tested for the TYR(Me)2 arginine-vasopressin as radioligand at 0.3 nM in A7r5 cells
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10.1016/S0960-894X(97)00050-4 |
| CHO | EC50 |
2 nM
Compound: AVP
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Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
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[PMID: 21428295] |
| CHO | EC50 |
8.3 nM
Compound: AVP
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Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
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[PMID: 21428295] |
| CHO-K1 | EC50 |
15 nM
Compound: 1, AVP, [Arg8]vasopressin
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Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
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[PMID: 21688787] |
| CHO-K1 | EC50 |
22 nM
Compound: AVP
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Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
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[PMID: 24874785] |
| COS-1 | EC50 |
41 nM
Compound: 2, AVP
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Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
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[PMID: 21117646] |
| Flp-In-293 | EC50 |
4.3 nM
Compound: 1, AVP, [Arg8]vasopressin
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Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay
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[PMID: 21688787] |
| HEK293 | EC50 |
0.0035 nM
Compound: AVP
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Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
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[PMID: 30896946] |
| HEK293 | EC50 |
0.004 nM
Compound: AVP
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Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
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[PMID: 30896946] |
| HEK293 | EC50 |
0.05 nM
Compound: 1, AVP, [Arg8]vasopressin
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Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay
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[PMID: 21688787] |
| HEK293 | EC50 |
0.05 nM
Compound: AVP
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Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
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[PMID: 24874785] |
| HEK293 | EC50 |
0.07 nM
Compound: 1, AVP, [Arg8]vasopressin
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Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
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[PMID: 21688787] |
| HEK293 | EC50 |
0.1 nM
Compound: AVP
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Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
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[PMID: 30896946] |
| HEK293 | EC50 |
0.24 nM
Compound: 1, AVP, [Arg8]vasopressin
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Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
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[PMID: 21688787] |
| HEK293 | EC50 |
0.24 nM
Compound: AVP
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Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
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[PMID: 24874785] |
| HEK293 | EC50 |
4.3 nM
Compound: AVP
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Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
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[PMID: 24874785] |
Argipressin binds to the vascular arginine vasopressin receptor, V1, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC50=5 nM)[1]. AVP-induced [Ca2+]i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca2+]i responses are 100 pM in non-neuronal cells in DRG culture[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 113-79-1
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Appearance Solid
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Molecular Weight 1084.23
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Formula C46H65N15O12S2
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Color White to off-white
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Synonyms
Arg8-vasopressin; AVP
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Sequence
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
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Sequence Shortening
CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen)
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Chem Biol
Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism. [Abstract]2026 Jan 6. PMID: 41495223 -
Chemosphere
Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 production. [Abstract]2021 Apr;269:128776. PMID: 33131727 -
Biochem Pharmacol
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. [Abstract]2022 Dec:206:115265. PMID: 36183803
Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).
Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Representative images of Argipressin (AVP) (300 µM) TUNEL staining.
Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative Western blot images.
Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.
Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]
Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.
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J Ethnopharmacol
Wuling San regulates AVPR2-cAMP-PKA-CREB pathway to delay cellular senescence and ameliorate acute kidney injury. [Abstract]2025 Apr 9:119679. PMID: 40216046 -
Front Pharmacol
Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice. [Abstract]2019 Nov 15;10:1380. PMID: 31824317 -
J Cell Mol Med
Effects of arginine vasopressin on the transcriptome of prefrontal cortex in autistic rat model. [Abstract]2022 Nov;26(21):5493-5505. PMID: 36239083 -
Front Neurosci
The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment. [Abstract]2022 Mar 25;16:838942. PMID: 35401102 -
BMC Pulm Med
Opposing responses of the rat pulmonary artery and vein to phenylephrine and other agents in vitro. [Abstract]2021 Jun 5;21(1):189. PMID: 34090386 -
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Solvent & Solubility
H2O : 100 mg/mL (92.23 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. [Content Brief]
[2]. Moriya T, et al. Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. [Content Brief]
[3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9223 mL | 4.6116 mL | 9.2231 mL | 23.0578 mL |
| 5 mM | 0.1845 mL | 0.9223 mL | 1.8446 mL | 4.6116 mL | |
| 10 mM | 0.0922 mL | 0.4612 mL | 0.9223 mL | 2.3058 mL | |
| 15 mM | 0.0615 mL | 0.3074 mL | 0.6149 mL | 1.5372 mL | |
| 20 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.1529 mL | |
| 25 mM | 0.0369 mL | 0.1845 mL | 0.3689 mL | 0.9223 mL | |
| 30 mM | 0.0307 mL | 0.1537 mL | 0.3074 mL | 0.7686 mL | |
| 40 mM | 0.0231 mL | 0.1153 mL | 0.2306 mL | 0.5764 mL | |
| 50 mM | 0.0184 mL | 0.0922 mL | 0.1845 mL | 0.4612 mL | |
| 60 mM | 0.0154 mL | 0.0769 mL | 0.1537 mL | 0.3843 mL | |
| 80 mM | 0.0115 mL | 0.0576 mL | 0.1153 mL | 0.2882 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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