BIEGi-1
BIEGi-1 is an EGFR inhibitor. BIEGi-1 effectively disrupts the EGFR-Rheb interaction in cells. BIEGi-1 robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) as well as mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant cells. BIEGi-1 shows strong antiproliferative effects on EGFR-mutant PC9 and HCC827 cells with IC50 values of 17 nM and 20 nM, respectively. BIEGi-1 can be used for the study of cancers harboring EGFR mutations, such as non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 1429497-30-2
- Formula: C36H37N7O3
- Molecular Weight:615.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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mTORC1 |
BIEGi-1 (25 nM, 12 h) effectively disrupts the interaction between EGFR and Rheb in PC9 cells (EGFR-mutant)[1].
BIEGi-1 (25 nM, 12 h) robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) and mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant PC9 and HCC827 cells[1].
BIEGi-1 (0.01-10000 nM, 72 h) exerts strong antiproliferative effects on PC9 and HCC827 cells, with IC50 values of 17 nM and 20 nM, respectively[1].
BIEGi-1 (200 nM, 24 h) inhibits mTORC1 activation induced by lysosome-localized LAMP2-V5-EGFR-TKD (WT and KD) in serum-starved HEK-293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:EGFR-mutant PC9 and HCC827 cells
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Concentration:25 nM
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Incubation Time:12 h
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Result:Reduced p-Y1068-EGFR and p-T389-S6K1 in EGFR-mutant PC9 and HCC827 cells.
Chemical Information
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CAS No. 1429497-30-2
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Molecular Weight 615.72
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Formula C36H37N7O3
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SMILES
O=C1N(C2=CC(NC(/C=C/C)=O)=CC=C2)C3=NC(NC4=C(C=C(N5CCN(CC5)C)C=C4)OC)=NC=C3C=C1CC6=CC=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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