HZ-1127
HZ-1127 is a thymic stromal lymphopoietin (TSLP) inhibitor. HZ-1127 selectively binds to TSLP, blocks receptor complex interaction, inhibits STAT5 activation, downstream inflammatory signaling, and TSLP-induced CCL17 and CCL22 secretion. HZ-1127 can be used for the research of allergic diseases and cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
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STAT5 |
HZ-1127-IgG1 and HZ-1127-IgG2 (Increasing concentrations; 2 h) bind to recombinant human TSLP-hFc with EC50 values of 0.023 μg/mL and 0.015 μg/mL, respectively, demonstrating potent dose-dependent binding[1].
HZ-1127 (12.5 μg/mL; 2 h) binds to an epitope on recombinant human TSLP that is either identical or highly similar to the epitope targeted by Tezepelumab (HY-P99366A)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Q969D9-1
TSLP
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HZ-1127 Related Classifications
HY-P992378 Related Classifications
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