KY02111
Based on 5 publication(s) in Google Scholar
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 1118807-13-8
- Formula: C18H17ClN2O3S
- Molecular Weight:376.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) KY02111
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Biological Activity
KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs[1].
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4[1].
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner[1].
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1118807-13-8
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Appearance Solid
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Molecular Weight 376.86
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Formula C18H17ClN2O3S
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Color White to off-white
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SMILES
O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Europace
The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes. [Abstract]2022 Dec 9;24(12):2015-2027. PMID: 35726875 -
Int J Mol Sci
Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer. [Abstract]2022 Oct 13;23(20):12219. PMID: 36293081 -
Biology (Basel)
Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes. [Abstract]2021 Oct 18;10(10):1062. PMID: 34681161 -
PLoS One
Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome. [Abstract]2024 Jan 5;19(1):e0287206. PMID: 38181028 -
Solvent & Solubility
DMSO : 33.33 mg/mL (88.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6535 mL | 13.2675 mL | 26.5351 mL | 66.3376 mL |
| 5 mM | 0.5307 mL | 2.6535 mL | 5.3070 mL | 13.2675 mL | |
| 10 mM | 0.2654 mL | 1.3268 mL | 2.6535 mL | 6.6338 mL | |
| 15 mM | 0.1769 mL | 0.8845 mL | 1.7690 mL | 4.4225 mL | |
| 20 mM | 0.1327 mL | 0.6634 mL | 1.3268 mL | 3.3169 mL | |
| 25 mM | 0.1061 mL | 0.5307 mL | 1.0614 mL | 2.6535 mL | |
| 30 mM | 0.0885 mL | 0.4423 mL | 0.8845 mL | 2.2113 mL | |
| 40 mM | 0.0663 mL | 0.3317 mL | 0.6634 mL | 1.6584 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5307 mL | 1.3268 mL | |
| 60 mM | 0.0442 mL | 0.2211 mL | 0.4423 mL | 1.1056 mL | |
| 80 mM | 0.0332 mL | 0.1658 mL | 0.3317 mL | 0.8292 mL |
KY02111 Related Classifications
HY-13815 Related Classifications
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