UNC8900
UNC8900 is a STING PROTAC degrader with a DC50 of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3094059-45-4
- Formula: C75H99N17O15S
- Molecular Weight:1510.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAKI-1 | DC50 |
0.924 μM
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STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates.
STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates.
|
37183204 |
In Vitro
UNC8900 (8 h) produces clear dose-dependent STING degradation in HKC-8 kidney cells after 8 hours[1].
UNC8900 (0-31.6 μM; 24 h) potently degrades STING with a DC50 of 0.924 μM and a maximum degradation level of 97.65% in Caki-1 renal cell carcinoma cells following 24 hour incubation[1].
UNC8900 (3 μM; 0-24 h) mediates very rapid STING degradation, with measurable STING protein reduction detected as early as 2 hours post-incubation in Caki-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HKC-8 human immortalized kidney cells
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Concentration:Dose range
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Incubation Time:8 h
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Result:Induces robust, dose-dependent reduction of STING protein expression in HKC-8 cells.
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Cell Line:Caki-1 human renal cell carcinoma cells
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Concentration:0-31.6 μM
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Incubation Time:24 h
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Result:Degrades STING protein with a DC50 of 0.924 μM, and achieves a maximum STING degradation (Dmax) value of 97.65% after 24 hours.
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Cell Line:Caki-1 human renal cell carcinoma cells
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Concentration:3 μM
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Incubation Time:0, 2, 4, 8, 12, 24 h
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Result:Results in robust STING degradation occurring within 2 hours, and near-complete STING loss is observed by 8 hours.
Chemical Information
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CAS No. 3094059-45-4
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Molecular Weight 1510.76
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Formula C75H99N17O15S
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SMILES
O=C(C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)C(OC)=C1)NCCOCCOCCOCCOCCC(N[C@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC8900 Related Classifications
HY-158047 Related Classifications
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