Cat. No.: HY-N1447

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Ganoderic acid A

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

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Pureté: 99.26%
CAS No.: 81907-62-2
Formule: C₃₀H₄₄O₇
Masse moléculaire:516.67

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

Ganoderic acid A Chemical Structure

CAS No.: 81907-62-2

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	7.25 μM Compound: 1	Cytotoxicity against human Bel7402 cells Cytotoxicity against human Bel7402 cells	[PMID: 23092389]
HeLa	IC₅₀	>300 μM Compound: 1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 23092389]
HepG2	CC₅₀	80 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31035236]
HepG2	IC₅₀	38.7 μM Compound: 17	Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24974349]
P388	IC₅₀	7.25 μM Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 23092389]
SGC-7901	IC₅₀	7.25 μM Compound: 1	Cytotoxicity against human SGC7901 cells Cytotoxicity against human SGC7901 cells	[PMID: 23092389]

In Vitro

A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma^[1].
Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression^[2].
Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner^[3].
Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81907-62-2
Appearance Solid
Masse moléculaire 516.67
Formule C₃₀H₄₄O₇
Color White to off-white
SMILES

CC1(C)C(CC[C@]2(C)C3=C([C@@]4([C@@H](O)C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(C[C@@H](C)C(O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

Publications (10)

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Journal Impact Factor

Exploration

MiR-29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation. [Abstract]

2025 Jun 10;5(4):20240363. PMID: 40873647
Cancer Lett

Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway. [Abstract]

2024 Jun 28:592:216898. PMID: 38670306
Geroscience

An mTOR inhibitor discovery system using drug-sensitized yeast. [Abstract]

2025 Jan 30. PMID: 39885115
J Pharm Pharmacol

Ganoderic acid A suppresses autophagy by regulating the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin. [Abstract]

2024 Apr 3;76(4):354-367. PMID: 38330446
J Biochem Mol Toxicol

Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway. [Abstract]

2019 Nov;33(11):e22392. PMID: 31503386

Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392. [Abstract]

Ganoderic acid A (GA-A) decreases the migration and invasion of GBM cells using transwell assay. U251 cells treated with GA-A, as experimental group. U251 cells treated with DMSO, as the negative control group (NC). GA-A obviously reduces the number of invaded U251 cells that goes through the Matrigel. GA-A markedly decreases the number of migrated cell that crossed the chamber. GA-A, ganoderic acid A; GBM, human glioblastoma. *P < .05 compared to NC.

Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392. [Abstract]

Western blot assay detects the apoptosis related protein expression. U251 cells treated with Ganoderic acid A (GA-A), as experimental group. U251 cells treated with DMSO, as negative control group (NC).

Ganoderic acid A purchased from MedChemExpress. Usage Cited in: J Biochem Mol Toxicol. 2019 Nov;33(11):e22392. [Abstract]

Western blot analysis determined the expression levels of AKT, p-AKT, mTOR, p-mTOR, p-P70S6K, and cyclin D1 after GA-A treatment.
Neuropsychiatr Dis Treat

Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression. [Abstract]

2021 Aug 14;17:2671-2681. PMID: 34421302
Hereditas

EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines. [Abstract]

2025 Jul 31;162(1):148. PMID: 40745342
Arch Oral Biol

Ganoderic acid A attenuates Porphyromonas gingivalis-induced adhesion molecule expression in gingival fibroblasts and tissues via inhibition of NLRP6 inflammasome activation. [Abstract]

2025 Oct 15:181:106429. PMID: 41108927
bioRxiv

2025 January 04.
Evid Based Complement Alternat Med

Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia. [Abstract]

2022 May 31:2022:2298665. PMID: 35685728

Solvant et solubilité

In Vitro:

DMSO : 62.5 mg/mL (120.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 50 mg/mL (96.77 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9355 mL

9.6774 mL

19.3547 mL

5 mM

0.3871 mL

1.9355 mL

3.8709 mL

10 mM

0.1935 mL

0.9677 mL

1.9355 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Radwan FF et al. Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem. 2015 Jan;116(1):102-14. [Content Brief]

[2]. Yao X et al. Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Planta Med. 2012 Nov;78(16):1740-8. [Content Brief]

[3]. Gill BS et al. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016 Sep 17. [Content Brief]

[4]. Shao J et al. [Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):619-24. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.9355 mL	9.6774 mL	19.3547 mL	48.3868 mL
	5 mM	0.3871 mL	1.9355 mL	3.8709 mL	9.6774 mL
	10 mM	0.1935 mL	0.9677 mL	1.9355 mL	4.8387 mL
	15 mM	0.1290 mL	0.6452 mL	1.2903 mL	3.2258 mL
	20 mM	0.0968 mL	0.4839 mL	0.9677 mL	2.4193 mL
	25 mM	0.0774 mL	0.3871 mL	0.7742 mL	1.9355 mL
	30 mM	0.0645 mL	0.3226 mL	0.6452 mL	1.6129 mL
	40 mM	0.0484 mL	0.2419 mL	0.4839 mL	1.2097 mL
	50 mM	0.0387 mL	0.1935 mL	0.3871 mL	0.9677 mL
	60 mM	0.0323 mL	0.1613 mL	0.3226 mL	0.8064 mL
	80 mM	0.0242 mL	0.1210 mL	0.2419 mL	0.6048 mL
DMSO	100 mM	0.0194 mL	0.0968 mL	0.1935 mL	0.4839 mL

Keywords

Ganoderic acid A

10 Cited Publications

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Ganoderic acid A

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Publications Citing Use of MedChemExpress (MCE) Ganoderic acid A

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Publications (10)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Ganoderic acid A Related Classifications

HY-N1447 Related Classifications