Mefexamide
Mefexamide (ANP-297) is a psychostimulant psychopharmaceutical and aryloxyacetic acid derivative antidepressant with dopaminergic activity. Mefexamide can be used for the research of depression.
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- CAS No.: 1227-61-8
- Formule: C15H24N2O3
- Masse moléculaire:280.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
Mefexamide (1 g; 15 min refluxed) undergoes acid hydrolysis to yield four breakdown products, and the compound exhibits distinct spectroscopic and chromatographic profiles, including a melting point of 112 °C, UV absorption maximum at 285 nm, and characteristic EI/CI mass spectra[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Mefexamide reverses Tetrabenazine (HY-B0590)-induced ptosis in male Wistar rats[2].
Mefexamide (5-20 mg/kg; i.v.; singer dose) significantly potentiates LSD-25-induced hyperthermia in male rabbits[2].
Mefexamide (5-20 mg/kg; i.v.; singer dose) potentiates Noradrenaline (HY-13715)-induced hyperthermia in male rabbits, with less significant effects than seen with LSD-25[2].
Mefexamide (10 mg/kg; i.v.; singer dose) protects against Reserpine (HY-N0480)-induced lowering of the bemegride convulsion threshold in male rabbits[2].
Mefexamide (10 mg/kg; i.v.; singer dose) does not significantly alter the EEG of normal male rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbit (male)[2]
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Dosage:5.0 mg/kg; 20.0 mg/kg
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Administration:i.v.; singer dose
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Result:Significantly potentiated LSD-25-induced hyperthermia in rabbits, mirroring the activity of cocaine.
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Animal Model:Rabbit (male)[2]
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Dosage:5.0 mg/kg; 20.0 mg/kg
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Administration:i.v.; singer dose
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Result:Potentiated noradrenaline-induced hyperthermia in rabbits, with a similar activity profile to that observed with LSD-25, though effects were less significant.
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Animal Model:Rabbit (male)[2]
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Dosage:10 mg/kg
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Administration:i.v.; singer dose
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Result:Reversed the reserpine-induced reduction in bemegride convulsion threshold, demonstrating antagonist activity similar to cocaine.
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Animal Model:Rabbit (male)[2]
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Dosage:10 mg/kg
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Administration:i.v.; singer dose
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Result:Did not significantly modify the EEG of normal male Giant of Flanders rabbits, with no notable induction of large slow waves.
Chemical Information
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CAS No. 1227-61-8
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Masse moléculaire 280.36
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Formule C15H24N2O3
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SMILES
O=C(NCCN(CC)CC)COC1=CC=C(OC)C=C1
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Synonyms
ANP-297
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mefexamide Related Classifications
HY-B0950 Related Classifications
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