Cat. No.: HY-N0213

Peiminine

(Synonyms: Verticinone; Raddeanine)

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models.

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Pureté: 99.89%
CAS No.: 18059-10-4
Formule: C₂₇H₄₃NO₃
Masse moléculaire:429.64

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Peiminine Chemical Structure

CAS No.: 18059-10-4

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target

Caspase 3

Caspase-8

Caspase-9

PARP-1

ERK1

ERK2

Bcl-2

p65

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In Vitro

Peiminine (2-6 μg/mL, 24 h) decreases the expressions of procaspase-3, procaspases-8 and -9 and increases the levels of caspase-3, 8, 9 protein in HepG2 cells^[1].
Peiminine (2-14 μg/mL, 24-72 h) displays the marked cytotoxicity to HepG2, Hela, SW480 and MCF-7 cells^[1].
Peiminine (2-6 μg/mL, 24 h) induces apoptosis in HepG2 cells^[1].
Peiminine (2-6 μg/mL, 24 h) induces HepG2 cells arrest at the G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2, Hela, SW480, MCF-7
Concentration:

2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL, 10 μg/mL, 12μg/mL, and 14 μg/mL
Incubation Time:

24 h, 48 h, 72 h
Result:

Exhibited a significant inhibition on the survival of HepG2, Hela, SW480 and MCF-7 cells with the IC₅₀ values were 4.58, 4.89, 5.07 and 5.12 μg/mL at 24 h, respectively.

Apoptosis Analysis^[1]

Cell Line:

HepG2
Concentration:

2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL
Incubation Time:

24 h
Result:

Dissociated chromosome to produce DNA fragments dose-dependently.

Cell Cycle Analysis^[1]

Cell Line:

HepG2
Concentration:

2 μg/mL, 4 μg/mL, 6 μg/mL
Incubation Time:

24 h
Result:

Decreased the percentage of G1 phases from 65.15% ± 0.78 to 49.55% ± 0.17 with the increase of concentrations.
Increased the percentage of G2/M phases from 17.32% ± 0.20 to 39.99% ± 0.47 with the increase of concentrations.

Western Blot Analysis^[1]

Cell Line:

HepG2
Concentration:

2 μg/mL, 4 μg/mL, 6 μg/mL
Incubation Time:

24 h
Result:

Reduced the expression of procaspase-3, PARP1, procaspases-8 and -9, and Bcl-2 at 2-6 μg/mL.
Increased caspase-3, 8, 9, PARP1 cleaved and Bax protein levels.

In Vivo

Peiminine (3mg/kg, intraperitoneal injection, single dose) alleviates inflammatory manifestations and mitigates intestinal tissue damage in an experimental model of ulcerative colitis^[2].
Peiminine (10 mg/kg, Intraperitoneal injection, once every 2 days for 6 weeks) prevents bone loss and fat formation in OVX-induced rat model^[3].
Peiminine (1-5 mg/kg, are applied to the dorsal skin, once daily for 16 days) inhibits serum IL-6 and TNF-α in the dinitrochlorobenzene (DNCB)-induced Allergic dermatitis animal model^[4].
Peiminine (2-5 mg/kg, Intraperitoneal injection, once a day for 4 weeks) has a cardioprotective effect against myocardial infarction-induced myocardial injury and fibrosis in myocardial infarction rat model^[5].
Peiminine (1-5 mg/kg, Intraperitoneal injection, single dose) can reduce the damage of inflammatory response to the body and the possibility of pulmonary edema in LPS-induced Acute lung injury model mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ulcerative colitis model^[2]
Dosage:

3mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells.
Reduced the levels of MPO and NO generated in the rectal tissue.
Reduced cell proliferation in spleen cell.
Decreased the production of f IL-1β, IL-6, and TNF-α cytokines.
Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2.

Animal Model:

Ovariectomized (OVX) rat model^[3]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Alleviated the bone loss caused by surgical castration.
Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.

Animal Model:

Allergic dermatitis model^[4]
Dosage:

1 mg/kg, 5 mg/kg
Administration:

were applied to the dorsal skin
Result:

Alleviated the bone loss caused by surgical castration.
Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.

Chemical Information

CAS No. 18059-10-4
Appearance Solid
Masse moléculaire 429.64
Formule C₂₇H₄₃NO₃
Color White to off-white
SMILES

[H][C@]12[C@]3([H])CC([C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])C[C@]([H])1[C@]5([H])CN6C[C@@H](C)CC[C@]([H])6[C@@](C)(O)[C@]([H])5CC2)=O
Synonyms

Verticinone; Raddeanine
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

All Cell Proliferation/Viability AssayFlow CytometryCell Migration/Invasion AssayWBIF

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Journal Impact Factor

Phytomedicine

Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway. [Abstract]

2023 Sep:118:154946. PMID: 37421766
Antioxidants (Basel)

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway. [Abstract]

2024 Jan 22;13(1):131. PMID: 38275656
Phytother Res

Peiminine regulates bone-fat balance by canonical Wnt/β-catenin pathway in an ovariectomized rat model. [Abstract]

2023 Jul;37(7):2841-2853. PMID: 36799485
Molecules

hERG Channel Blockade and Antagonistic Interactions of Three Steroidal Alkaloids from Fritillaria Species. [Abstract]

2025 Sep 25;30(19):3882. PMID: 41097303
Molecules

Metabolite Profiling and Anti-Inflammatory Activities of Fritillaria cirrhosa D. Don Bulbs Derived from Tissue Culture. [Abstract]

2025 Jan 31;30(3):623. PMID: 39942727
Discov Oncol

Peiminine suppresses prostate cancer progression by regulating cell proliferation, motility, apoptosis, and mitochondrial dysfunction. [Abstract]

2025 Nov 7;16(1):2060. PMID: 41201738

Peiminine purchased from MedChemExpress. Usage Cited in: Discov Oncol. 2025 Nov 7;16(1):2060. [Abstract]

CCK-8 assay for evaluating the viability of PCa cells treated with various concentrations of Peiminine for 24, 48, or 72 h.

Peiminine purchased from MedChemExpress. Usage Cited in: Discov Oncol. 2025 Nov 7;16(1):2060. [Abstract]

Flow cytometry analysis of cell cycle distribution of PCa cells treated with Peiminine (10, 20, 40 μM).

Peiminine purchased from MedChemExpress. Usage Cited in: Discov Oncol. 2025 Nov 7;16(1):2060. [Abstract]

Wound healing assay for evaluating PCa cell migration treated with Peiminine (10, 20, 40 μM).

Peiminine purchased from MedChemExpress. Usage Cited in: Discov Oncol. 2025 Nov 7;16(1):2060. [Abstract]

Representative images of Western blotting showing protein levels of EMT-related markers treated with Peiminine (10, 20, 40 μM).

Peiminine purchased from MedChemExpress. Usage Cited in: Discov Oncol. 2025 Nov 7;16(1):2060. [Abstract]

Detection of mitochondrial ROS in PCa cells using the MitoSOX fluorescent probe treated with Peiminine (10, 20, 40 μM).
Tissue Cell

Peiminine triggers ferroptosis to inhibit breast cancer growth through triggering Nrf2 signaling. [Abstract]

2024 Apr:87:102323. PMID: 38412577

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (232.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3275 mL

11.6376 mL

23.2753 mL

5 mM

0.4655 mL

2.3275 mL

4.6551 mL

10 mM

0.2328 mL

1.1638 mL

2.3275 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (292 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chao X, et al. The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells [J]. PLoS One, 2019, 14(1): e0201864. [Content Brief]

[2]. Ranjbar Bushehri M, et al. Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model [J]. Inflammopharmacology, 2023: 1-9. [Content Brief]

[3]. Gu H, et al. Peiminine regulates bone-fat balance by canonical Wnt/β-catenin pathway in an ovariectomized rat mode [J]. Phytotherapy Research, 2023. [Content Brief]

[4]. Lim J M, et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro [J]. International immunopharmacology, 2018, 56: 135-142. [Content Brief]

[5]. Chen P, et al. Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway [J]. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2022, 26(2): 87-94. [Content Brief]

[6]. Du B, et al. Peiminine attenuates acute lung injury induced by LPS through inhibiting lipid rafts formation [J]. Inflammation, 2020, 43: 1110-1119. [Content Brief]

[7]. Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3275 mL	11.6376 mL	23.2753 mL	58.1882 mL
	5 mM	0.4655 mL	2.3275 mL	4.6551 mL	11.6376 mL
	10 mM	0.2328 mL	1.1638 mL	2.3275 mL	5.8188 mL
	15 mM	0.1552 mL	0.7758 mL	1.5517 mL	3.8792 mL
	20 mM	0.1164 mL	0.5819 mL	1.1638 mL	2.9094 mL
	25 mM	0.0931 mL	0.4655 mL	0.9310 mL	2.3275 mL
	30 mM	0.0776 mL	0.3879 mL	0.7758 mL	1.9396 mL
	40 mM	0.0582 mL	0.2909 mL	0.5819 mL	1.4547 mL
	50 mM	0.0466 mL	0.2328 mL	0.4655 mL	1.1638 mL
	60 mM	0.0388 mL	0.1940 mL	0.3879 mL	0.9698 mL
	80 mM	0.0291 mL	0.1455 mL	0.2909 mL	0.7274 mL
	100 mM	0.0233 mL	0.1164 mL	0.2328 mL	0.5819 mL

Peiminine

7 Cited Publications

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Peiminine

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

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Publications Citing Use of MedChemExpress (MCE) Peiminine

Voir tous les produits spécifiques à Isoform Caspase

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Voir tous les produits spécifiques à Isoform PARP

Voir tous les produits spécifiques à Isoform p38 MAPK

Voir tous les produits spécifiques à Isoform ERK

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Publications (7)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Peiminine Related Classifications

Cat. No.: HY-N0213