ABS-752
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma.
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- CAS No.: 2761170-84-5
- Formule: C14H14FN3O3
- Masse moléculaire:291.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NSG mice (Hep3B cells)[1]
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Dosage:1, 3, 10 mg/kg
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Administration:Po; daily for 14 days
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Result:Showed anticancer activity in a dose-dependent manner.
Chemical Information
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CAS No. 2761170-84-5
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Masse moléculaire 291.28
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Formule C14H14FN3O3
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SMILES
O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABS-752 Related Classifications
HY-W599279 Related Classifications
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