APG808
APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human IgG1 kappa
Human
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IL-4Rα/IL4R/CD124 |
APG808 has a high affinity for human FcRn at pH 6.0, reduced affinity for human FcγRI, FcγRIIIa (F158), and FcγRIIIa (V158), and no detectable binding to human FcγRIIa (H131), FcγRIIa (R131), FcγRIIIb, or C1q[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-inf | CL | Vss | Bioavailability | T1/2 |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 25.9 mg/kg | s.c. | 9.77 × 106 ng·h/mL | 2.79 | 101.80 mL/kg | 97.51 % | 27.18 |
IL-4Ra/CD124
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[APG808]
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Synonyms
PR001
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APG808 Related Classifications
HY-P992034 Related Classifications
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