ARN24139
ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo.
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- CAS No.: 2699768-78-8
- Formule: C24H16F3N3O4S
- Masse moléculaire:499.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
ARN24139(compound 3f) has antiproliferative activity on DU145, HeLa and A549 cells with the IC50 values of 4.7, 3.8 and 3.1μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameter | IV (3 mg/kg) | PO (10 mg/kg) |
| Cmax(ng/mL) | 7366 | 428 |
| Tmax(min) | 5 | 120 |
| AUCplasma(min*ng/mL) | 295528 | 77385 |
| t1/2(min) | 30 | 190 |
| Vd(L/kg) | 3 | 18 |
| CL(L/min/kg) | 0.004 | - |
| F(%) | 8 | 8 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2699768-78-8
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Masse moléculaire 499.46
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Formule C24H16F3N3O4S
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SMILES
O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ARN24139 Related Classifications
HY-148719 Related Classifications
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