CD666
CD666 is a selective retinoic acid receptor-γ (RAR-γ) agonist with a Kd of 68 nM. CD666 inhibits proliferation of cancer cells and shows synergistical effects and anti-AP-1 activity with IFN-γ. CD666 can be used for the research of breast cancer.
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- CAS No.: 144006-45-1
- Formule: C24H28O3
- Masse moléculaire:364.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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RAR-γ 68 nM (Kd) |
CD666 binds selectively to recombinant RAR-γ with a Kd of 68 nM, showing ~33-fold and ~34-fold lower affinity for RAR-α (Kd = 2240 nM) and RAR-β (Kd = 2300 nM), respectively[1].
CD666 (0.1-1000 μM) potently inhibits proliferation of RA-sensitive MCF-7, ZR-75-1, T47D, and SKBR-3 human breast cancer cell lines, but does not inhibit proliferation of Retinoic acid (HY-14649 )-resistant 734-B and BT-20 cell lines when used alone[1].
CD666 acts synergistically with IFN-γ to inhibit proliferation of MCF-7, SKBR-3, BT-20, ZR-75-1, T47D, and 734-B human breast cancer cell lines, with combination
index values < 1 across all tested inhibitory concentrations[1].
CD666 (1 μM; 24 h) alone does not suppress TPA-mediated AP-1 activity in MCF-7 human breast cancer cells, but in combination with IFN-γ, it significantly reduces AP-1 promoter activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 144006-45-1
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Masse moléculaire 364.48
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Formule C24H28O3
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SMILES
CC1(C2=CC(C(O)/C=C/C3=CC=C(C=C3)C(O)=O)=CC=C2C(C)(CC1)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD666 Related Classifications
HY-183139 Related Classifications
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