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Cat. No.: HY-N3716

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Dehydroglyasperin D

Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi.

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CAS No.: 517885-72-2
Formule: C₂₂H₂₄O₅
Masse moléculaire:368.42

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Data Sheet (267 KB)

Dehydroglyasperin D Chemical Structure

CAS No.: 517885-72-2

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Fluorescent Dye

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Activité biologique
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Description

IC₅₀ & Target

COX-2^[1]

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Chemical Information

CAS No. 517885-72-2
Masse moléculaire 368.42
Formule C₂₂H₂₄O₅
SMILES

OC1=CC=C(C2=CC3=C(OC)C(C/C=C(C)\C)=C(OC)C=C3OC2)C(O)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33(5):917-21. [Content Brief]

[2]. Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19(1):135-42. [Content Brief]

[3]. Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32(8):982-988. [Content Brief]

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Dehydroglyasperin D

Voir tous les produits spécifiques à Isoform COX

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Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Dehydroglyasperin D Related Classifications

HY-N3716 Related Classifications