Derrone
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity.
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- CAS No.: 76166-59-1
- Formule: C20H16O5
- Masse moléculaire:336.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
13 μM
Compound: 16, derrone
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Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
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[PMID: 17158054] |
| U-937 | IC50 |
20 μM
Compound: 16, derrone
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Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
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[PMID: 17158054] |
| U-937 | IC50 |
26 μM
Compound: 16, derrone
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Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
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[PMID: 17158054] |
In Vitro
Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively[1].
Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2].
Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 76166-59-1
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Masse moléculaire 336.34
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Formule C20H16O5
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SMILES
O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C=C4
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hoang NT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39(6):935-45. [Content Brief]
[2]. Kang MJ, et al. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells. PLoS One. 2019 Jun 19;14(6):e0218659. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Derrone Related Classifications
HY-N3737 Related Classifications
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