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Cat. No.: HY-121285

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Dioxadrol

Dioxadrol is an uncompetitive NMDA receptor (PCP binding site) antagonist, with a K_i value of 10.9 nM in pigs. Dioxadrol binds to the phencyclidine (PCP) binding site within the cation channel associated with the NMDA receptor, thereby blocking cation influx. Dioxadrol possesses local anesthetic, spasmolytic and central nervous system activities, including phencyclidine-like dissociative anesthetic properties. Dioxadrol can be used in the research of Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, central nervous system trauma, and epilepsy.

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CAS No.: 6495-46-1
Formule: C₂₀H₂₃NO₂
Masse moléculaire:309.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Dioxadrol Chemical Structure

CAS No.: 6495-46-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
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Description

IC₅₀ & Target^[1]

NMDA Receptor

10.9 nM (Ki)

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In Vitro

Dioxadrol (compound dioxadrol ((±)-3)) (150 min) potently binds to the PCP binding site of NMDA receptors in porcine cerebral cortex membranes, with a K_i value of 10.9 nM. Its affinity is comparable to that of commercially available dextromethorphan, and it shows high selectivity against off-target receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6495-46-1
Masse moléculaire 309.40
Formule C₂₀H₂₃NO₂
SMILES

C1(C2OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC2)NCCCC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Banerjee A, et al. Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorganic & medicinal chemistry. 2010 Nov 15;18(22):7855-67. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Dioxadrol

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